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  4. Dextran sulfate sodium salt (MW 6500-10000)

Dextran sulfate sodium salt (MW 6500-10000)  (Synonyms: 硫酸葡聚糖钠盐 (MW 6500-10000); DSS (MW 6500-10000); DXS (MW 6500-10000))

目录号: HY-116282W
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Dextran sulfate sodium salt (DSS) (MW 6500-10000) 是一种脱水葡萄糖聚合物，分子量约为 6500-10000。不同分子量的 Dextran sulfate sodium salt 表现出不同的生物活性。Dextran sulfate sodium salt (MW 6500-10000) 对 HIV-1 和 HIV-2 具有抗病毒活性。Dextran sulfate sodium salt (MW 6500-10000) 可阻断病毒体与 CD4⁺ T 淋巴细胞的结合并抑制合胞体的形成。Dextran sulfate sodium salt (MW 6500-10000) 还因其细胞保护作用而预防实验性尿石症。此外，由于其生物相容性和高电荷特性，Dextran sulfate sodium salt (MW 6500-10000) 是用于制备药物递送体系的合适选择。

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Dextran sulfate sodium salt (MW 6500-10000)

Dextran sulfate sodium salt (MW 6500-10000) Chemical Structure

CAS No. : 9011-18-1

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Dextran sulfate sodium salt (MW 6500-10000) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dextran sulfate sodium salt (DSS) (MW 6500-10000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 6500-10000) has antiviral activity against HIV-1 and HIV-2. Dextran sulfate sodium salt (MW 6500-10000) blocks the binding of virions to CD4⁺ T lymphocytes and inhibits syncytia formation. Dextran sulfate sodium salt (MW 6500-10000) also prevents experimental urolithiasis due to its cytoprotective actions. Moreover, because of its biocompatible and highly charged properties, Dextran sulfate sodium salt (MW 6500-10000) is a suitable choice for pharmaceutical systems[1][2][3][4][5][6].

体外研究
(In Vitro)

抗病毒活性：
Dextran sulfate sodium salt (MW 8000) (6.75 μM, 48 小时) 抑制 CD4+ ATH8 细胞与 HIV-1 感染的 H9 细胞间的合胞体形成[1]。

细胞保护活性：
Dextran sulfate sodium salt (MW 6500-10000) (100, 500 μM, 24 小时) 保护小鼠和人类 β 细胞免受 IL-1β、TNF-α 和 IFN-γ 组合引起的死亡[3]。
Dextran sulfate sodium salt (MW 6500-10000) (100, 500 μM, 24 小时) 降低 IFN-γ、TNF-α 和 IL-1β 在人胰岛中的信号通路[3]。

用作涂层材料：
Dextran sulfate sodium salt (MW 6500-10000) 可用于涂覆量子点，以靶向巨噬细胞上的清道夫受体[4]。
Dextran sulfate sodium salt (MW 6500-10000) 可用于涂覆 PEI-GLU 层 (一种酶多层组合生物催化剂)，以产生更亲水的表面[5]。
Dextran sulfate sodium salt (MW 6500-10000) 可用于配制蜂毒素/DSS 纳米复合物 (基于带正电荷的肽和聚电解质之间的强静电相互作用)，克服了蜂毒素的高急性毒性和短体内半衰期[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dextran sulfate sodium salt (MW 6500-10000) 相关抗体:
体内研究
(In Vivo)

Dextran sulfate sodium salt (MW 8000) (65 mg/kg，溶于 0.2 mL 生理盐水，腹腔注射，每日一次) 可预防大鼠实验性尿石症。DSS 与尿液中溶解的钙离子形成可溶性复合物，从而防止钙盐结晶[2]。
Dextran sulfate sodium salt (MW 6500-10000) (10 mg/kg，腹腔注射，持续 4 周) 可预防糖尿病前期 NOD 小鼠患上 T1D[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD mice[3]
Dosage: 10 mg/kg
Administration: i.p., for 4 weeks (8-week-old NOD mice); i.p., for 11 weeks (10-week-old prediabetic NOD female mice);
Result: Improved glucose tolerance, and diminished β-cell death and insulitis (8-week-old NOD mice).
Lowers blood glucose and increased plasma insulin and β-cell mass (10-week-old prediabetic NOD female mice).
Reduced the expression of genes such as Il-1β, Tnf-α, Cxcl9, and Cxcl10 in pancreas (8-week-old NOD mice).
分子量

6500-10000

CAS 号
中文名称

硫酸葡聚糖钠盐 (MW 6500-10000)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dextran sulfate sodium salt (MW 6500-10000) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dextran sulfate sodium salt (MW 6500-10000)9011-18-1DSS (MW 6500-10000) DXS (MW 6500-10000)硫酸葡聚糖钠盐 (MW 6500-10000)HIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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