2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. DM-4103

DM-4103 是一种 Tolvaptan (HY-17000) 的主要代谢物，主要通过肝脏中的 CYP3A4 酶代谢。DM-4103 在 SCHH 细胞中抑制人体肝脏转运蛋白 NTCP、BSEP、MRP2、MRP3、MRP4 (IC50 分别为 16.3、4.15、51.0、44.6、4.26 μM) 和胆汁酸转运的能力。DM-4103 可用于常染色体显性多囊肾病 (ADPKD) 的研究。

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DM-4103 Chemical Structure

DM-4103 Chemical Structure

CAS No. : 1346599-56-1

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DM-4103 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DM-4103 is a major metabolite of Tolvaptan (HY-17000) that is metabolized primarily by the CYP3A4 enzyme in the liver. DM-4103 inhibits the ability of human liver transporters NTCP, BSEP, MRP2, MRP3, MRP4 (IC50 values are 16.3, 4.15, 51.0, 44.6, 4.26 μM, respectively) and bile acid transport in SCHH cells. DM-4103 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD)[1][2].

分子量

478.92

Formula

C26H23ClN2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DM-4103 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DM-41031346599-56-1DM4103DM 4103P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243NTCPBSEPMRP2MRP3MRP4autosomal dominant polycystic kidney disease (ADPKD)Inhibitorinhibitorinhibit

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