1. Apoptosis
  2. Apoptosis
  3. (E/Z)-E64FC26

(E/Z)-E64FC26 

目录号: HY-122895A
产品使用指南

(E/Z)-E64FC26 是 E-E64FC26 和 Z-E64FC26 的混合物。E64FC26 (E-E64FC26) 是蛋白质二硫键异构酶 (PDI) 家族的一种有效的泛抑制剂,对 PDIA1、PDIA3、PDIA4、TXNDC5 和 PDIA6 的 IC50 分别为 1.9、20.9、25.9、16.3 和 25.4 μM。E64FC26 显示抗骨髓瘤活性。

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(E/Z)-E64FC26 Chemical Structure

(E/Z)-E64FC26 Chemical Structure

CAS No. : 2285446-67-3

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Description

(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity[1][2].

Molecular Weight

340.38

Formula

C₁₉H₂₃F₃O₂

CAS No.

2285446-67-3

SMILES

OC1=CC2=C(/C(C=C2C(F)(F)F)=C/CCCCCCCC)C=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (293.79 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9379 mL 14.6895 mL 29.3789 mL
5 mM 0.5876 mL 2.9379 mL 5.8758 mL
10 mM 0.2938 mL 1.4689 mL 2.9379 mL
*

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储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
  • 摩尔计算器

  • 稀释计算器

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Keywords:

(E/Z)-E64FC26Apoptosismultiplemyelomaisomerasecytotoxicsurvivalpan-styleCD-1miceNSG ERoxidativestressInhibitorinhibitorinhibit

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产品名称:
(E/Z)-E64FC26
目录号:
HY-122895A
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