2. Others Membrane Transporter/Ion Channel
  3. Isotope-Labeled Compounds Apical Sodium-Dependent Bile Acid Transporter
  4. Elobixibat-d5

Elobixibat-d5  (Synonyms: A 3309-d5; AZD 7806-d5)

目录号: HY-15790S
产品使用指南 技术支持

Elobixibat-d5 是氘代标记的 Elobixibat (HY-15790)。Elobixibat (A 3309；AZD 7806) 是一种口服有效的胆汁酸转运体 (IBAT) 抑制剂，IC50 分别为 0.53 nM (人类 IBAT)，0.13 nM (小鼠 IBAT)，5.8 nM (犬类 IBAT)。Elobixibat 可降低 LDL 胆固醇，增加血清 GLP-1，促进结肠运动，并具有治疗代谢综合征的潜力。Elobixibat 可用于老年慢性功能性便秘 (CIC)、血脂异常、非酒精性肝炎和肝脏肿瘤的研究。

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Elobixibat-d<sub>5</sub>

Elobixibat-d5 Chemical Structure

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Other Forms of Elobixibat-d5:

Elobixibat-d5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Elobixibat-d5 is the deuterium labeled Elobixibat (HY-15790). Elobixibat (A 3309; AZD 7806) is orally active, bile acid transporter (IBAT) inhibitor with IC50 values ??of 0.53 nM (human IBAT), 0.13 nM (mouse IBAT), and 5.8 nM (canine IBAT). Elobixibat can lower LDL cholesterol, increase serum GLP-1, promote colonic motility, and has the potential to treat metabolic syndrome. Elobixibat can be used in the study of chronic functional constipation (CIC), dyslipidemia, non-alcoholic hepatitis, and liver tumors in the elderly[1][2][3][4].

IC50 & Target

IC50: 0.53±0.17 nM (human IBAT), 0.13±0.03 nM (mouse IBAT), 5.8±1.6 nM (canine IBAT)[1].
体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物研发过程中定量分析的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而备受关注[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Elobixibat-d5 相关抗体:
分子量

700.92

Formula

C36H40D5N3O7S2
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Elobixibat-d5 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elobixibat-d5A 3309-d5 AZD 7806-d5Isotope-Labeled CompoundsApical Sodium-Dependent Bile Acid TransporterASBTIleal Bile Acid TransporterIBATSLC10A2Inhibitorinhibitorinhibit

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