1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. TRP Channel
  3. Englerin A

Englerin A 是一种有效和选择性的 TRPC4TRPC5 通道的活化剂,EC50 值分别为 11.2 和 7.6 nM。Englerin A 通过增加 Ca2+ 内流和 Ca2+ 细胞超负荷来诱导肾癌细胞死亡。

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Englerin A Chemical Structure

Englerin A Chemical Structure

CAS No. : 1094250-15-3

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查看 TRP Channel 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload[1][2][3].

IC50 & Target[1]

hTRPC4

11.2 nM (EC50)

hTRPC5

7.6 nM (EC50)

体外研究
(In Vitro)

Englerin A (0.15-2500 nM; 48 h) characteristic concentration-dependent suppresses cells growth of the A-498 cells treated with the control siRNA while has little effect on the growth of cells treated with TRPC4 siRNAs[3].
Englerin A (0.001nM-10 μM; 48 h) inhibits cells viability in HEK293T cells overexpressing TRPC5[3].
Englerin A (3 nM; 1-240 s) evokes sustained elevation of the intracellular Ca2+ concentration within 1 min in HEK 293 cells over-expressing human TRPC4[1].
Englerin A (0.1-1000 nM; 1-300 s) evokes intracellular Ca2+ elevations in A498 cells as well with an EC50 of 10 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Englerin A (5 mg/kg; i.p daily except Sunday) markedly inhibits tumor growth during the 2-week treatment period in mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

442.54

Formula

C26H34O6

CAS 号
性状

固体

颜色

White to light yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

Methanol 中的溶解度 : 30 mg/mL (67.79 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2597 mL 11.2984 mL 22.5968 mL
5 mM 0.4519 mL 2.2597 mL 4.5194 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.50%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 2.2597 mL 11.2984 mL 22.5968 mL 56.4921 mL
5 mM 0.4519 mL 2.2597 mL 4.5194 mL 11.2984 mL
10 mM 0.2260 mL 1.1298 mL 2.2597 mL 5.6492 mL
15 mM 0.1506 mL 0.7532 mL 1.5065 mL 3.7661 mL
20 mM 0.1130 mL 0.5649 mL 1.1298 mL 2.8246 mL
25 mM 0.0904 mL 0.4519 mL 0.9039 mL 2.2597 mL
30 mM 0.0753 mL 0.3766 mL 0.7532 mL 1.8831 mL
40 mM 0.0565 mL 0.2825 mL 0.5649 mL 1.4123 mL
50 mM 0.0452 mL 0.2260 mL 0.4519 mL 1.1298 mL
60 mM 0.0377 mL 0.1883 mL 0.3766 mL 0.9415 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Englerin A
目录号:
HY-133168
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