2. Metabolic Enzyme/Protease Neuronal Signaling
  3. FAAH
  4. FAAH-IN-7

FAAH-IN-7 是一种可逆且有效的 FAAH 抑制剂，IC50 为 8.29 nM。FAAH-IN-7 能够抑制 1321N1星形胶质细胞氧化应激，在离体神经炎症模型中表现出显著的神经保护作用。

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FAAH-IN-7

FAAH-IN-7 Chemical Structure

CAS No. : 3037600-36-2

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FAAH-IN-7 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FAAH-IN-7 is a reversible and potent FAAH inhibitor with an IC50 value of 8.29 nM. FAAH-IN-7 suppresses oxidative stress in 1321N1 astrocytes and exhibits notable neuroprotective effect in ex vivo neuroinflammation model[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
NIH3T3 IC50
6.4 μM
Compound: 4e
Cytotoxicity against mouse NIH3T3 cells assessed as inhibition of cell growth measured for 24 hrs by neutral red uptake assay
Cytotoxicity against mouse NIH3T3 cells assessed as inhibition of cell growth measured for 24 hrs by neutral red uptake assay
[PMID: 36462439]
体外研究
(In Vitro)

FAAH-IN-7 (compound 4e) (10 nM-30 μM; 24 h) has no cytotoxicity against mouse fibroblasts NIH3T3 and human astrocytes cell line 1321N1 with Ki values >10 μM[1].
FAAH-IN-7 (10 nM, 100 nM; 30 min) inhibits FAAH through a reversible mechanism in the case of rapid dilution. The rapid dilution disrupts the equilibrium between the inhibitor and the enzyme, resulting in enzymatic activity recovery[1].
FAAH-IN-7 (1 nM-1 μM; 24 h) significantly reduces ROS production starting from the 10 nM concentration in 1321N1 astrocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FAAH-IN-7 相关抗体:

Cell Viability Assay[1]

Cell Line: 1321N1 human astrocytes
Concentration: 10 nM, 100 nM, 1 μM, 10 μM, and 30 μM
Incubation Time: 24 hours
Result: Showed no cytotoxicity against 1321N1 human astrocytes.
体内研究
(In Vivo)

FAAH-IN-7 (compound 4e) shows anti-inflammatory effects in inflammation-induced neurodegenerated ex vivo cultures of rat hippocampal explants[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

447.53

Formula

C26H29N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FAAH-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAAH-IN-73037600-36-2FAAHFatty acid amide hydrolaseInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-151919
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