Foxy-5 

Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model^[1][2][3].

WNT5A^[2]

Foxy-5 (100 μM, 24 h) 在 DU145 细胞中可抑制肿瘤细胞的侵袭^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Foxy-5 (2 mg/kg, 腹腔注射, 每天注射 9 次, 7-23 天) 在人结肠癌异种移植小鼠模型中减少结肠癌干细胞的数量^[2]。
Foxy-5 (2 mg/kg, 腹腔注射, 每天 1 次, 3-9 周) 在前列腺癌异种移植小鼠模型中显著降低 WNT5A 低 DU145 前列腺癌细胞的早期转移扩散^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

694.77

C₂₆H₄₂N₆O₁₂S₂

881188-51-8

固体

White to off-white

{For}-Met-Asp-Gly-Cys-Glu-Leu

{For}-MDGCEL

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

• [1]. Säfholm A, et al. The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin Cancer Res. 2008 Oct 15;14(20):6556-63.  [Content Brief]

  [2]. Osman J, et al. The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer. Anticancer Res. 2019 Apr;39(4):1719-1728.  [Content Brief]

  [3]. Canesin G, et al. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One. 2017 Sep 8;12(9):e0184418.  [Content Brief]