2. Gene
  3. Ahr - aryl-hydrocarbon receptor Gene

Ahr - aryl-hydrocarbon receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ah; In; Ahh; Ahre; bHLHe76

基因 ID: 11622 | 基因类型: protein coding

关于 Ahr

功能概要

The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing Enzymes such as Cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Ahr 基因产物(2)

mRNA Protein Name
NM_001314027.1 NP_001300956.1 aryl hydrocarbon receptor isoform 2
NM_013464.4 NP_038492.1 aryl hydrocarbon receptor isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
1313028 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
1313028 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
18223155 MGI
enables E-box binding IDA
IDA: 通过直接分析推断
20106950 MGI
enables aryl hydrocarbon receptor binding IPI
IPI: 通过物理相互作用推断
24001774 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
24001774 MGI
enables nuclear receptor activity IDA
IDA: 通过直接分析推断
1314586 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8657146 MGI
enables protein heterodimerization activity IDA
IDA: 通过直接分析推断
24001774 MGI
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
11230806 MGI
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
24001774 MGI
enables protein-folding chaperone binding IPI
IPI: 通过物理相互作用推断
15581363 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
1605850 MGI
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28396409 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B cell homeostasis IMP
IMP: 通过突变表型推断
7732381 MGI
involved in T cell homeostasis IMP
IMP: 通过突变表型推断
7732381 MGI
involved in blood circulation IMP
IMP: 通过突变表型推断
10973493 MGI
involved in blood vessel development IMP
IMP: 通过突变表型推断
10973493 MGI
involved in blood vessel morphogenesis IMP
IMP: 通过突变表型推断
10973493 MGI
involved in blood vessel remodeling IMP
IMP: 通过突变表型推断
10973493 MGI
involved in branching involved in blood vessel morphogenesis IMP
IMP: 通过突变表型推断
10973493 MGI
involved in camera-type eye development IMP
IMP: 通过突变表型推断
10973493 MGI
involved in cardiac left ventricle morphogenesis IMP
IMP: 通过突变表型推断
14644620 MGI
involved in cell morphogenesis IMP
IMP: 通过突变表型推断
10973493 MGI
involved in cellular response to 2,3,7,8-tetrachlorodibenzodioxine IDA
IDA: 通过直接分析推断
33436590 MGI
involved in cellular response to 3-methylcholanthrene IDA
IDA: 通过直接分析推断
1314586 MGI
involved in circadian regulation of gene expression IDA
IDA: 通过直接分析推断
20106950 MGI
involved in circumferential growth involved in left ventricle morphogenesis IMP
IMP: 通过突变表型推断
14644620 MGI
acts upstream of or within gland development IMP
IMP: 通过突变表型推断
12151645 MGI
involved in glomerulus morphogenesis IMP
IMP: 通过突变表型推断
14644620 MGI
involved in immune system process IMP
IMP: 通过突变表型推断
7732381 MGI
involved in kidney morphogenesis IMP
IMP: 通过突变表型推断
14644620 MGI
involved in liver development IMP
IMP: 通过突变表型推断
7732381 MGI
involved in lymphocyte homeostasis IMP
IMP: 通过突变表型推断
7732381 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
20106950 MGI
involved in negative regulation of systemic arterial blood pressure IMP
IMP: 通过突变表型推断
14644620 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18223155 MGI
involved in negative regulation of vasoconstriction IMP
IMP: 通过突变表型推断
14644620 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
1313028 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
20106950 MGI
acts upstream of or within positive regulation of RNA polymerase II transcription preinitiation complex assembly IDA
IDA: 通过直接分析推断
8215422 MGI
involved in positive regulation of cell size IMP
IMP: 通过突变表型推断
10973493 MGI
involved in positive regulation of growth rate IMP
IMP: 通过突变表型推断
7732381 MGI
involved in post-embryonic hemopoiesis IMP
IMP: 通过突变表型推断
8692887 MGI
acts upstream of or within prostate gland development IMP
IMP: 通过突变表型推断
12151645 MGI
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
1314586 MGI
acts upstream of or within reproductive structure development IMP
IMP: 通过突变表型推断
12151645 MGI
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
7961644 MGI
involved in spleen development IMP
IMP: 通过突变表型推断
7732381 MGI
involved in transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
1314586 MGI
involved in vasculature development IMP
IMP: 通过突变表型推断
16443691 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12215427 MGI
located in cytosol IDA
IDA: 通过直接分析推断
17569696 MGI
is active in nucleus IDA
IDA: 通过直接分析推断
33436590 MGI
located in nucleus IDA
IDA: 通过直接分析推断
1314586 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

aryl hydrocarbon receptor

ah receptor

dioxin receptor

相关产品

Approval
生物活性分子 (11)
目录号 产品名 作用方式
纯度 是否罕见病
HY-109044 Tapinarof Agonist 99.95% 否
HY-N0178 Diosmin Agonist 99.51% 是
HY-A0083 Methacholine chloride Agonist ≥98.0% 是
HY-B0311 Carbidopa Modulator 98.0% 是
HY-B0678 Metaxalone 99.77% 否
HY-17357 Nepafenac Inhibitor 99.56% 否
HY-W017113 2-Mercaptobenzothiazole Activator 99.85% 是
HY-B0311A Carbidopa monohydrate Modulator 98.0% 是
HY-17479 Amfenac / 否
HY-A0083B Methacholine bromide Agonist / 否
HY-B0678R Metaxalone (Standard) / 否
Clinical Phase
生物活性分子 (6)
目录号 产品名 作用方式
纯度 Phase
HY-B2132 Tryptamine 99.77% Phase 3
HY-15001 Stemregenin 1 Antagonist 99.95% Phase 2
HY-N0170 Indole-3-carbinol 98.87% Phase 2
HY-16031 AFP464 free base Inhibitor / Phase 2
HY-135829 BAY 2416964 Antagonist 99.59% Phase 1
HY-111449 BAY-218 Antagonist 99.78% Phase 1
Pre-clinical Phase
生物活性分子 (140)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12028 PD98059 99.94% 否
HY-12684 CH-223191 Antagonist 99.96% 否
HY-15484 Pifithrin-α hydrobromide 98.58% 否
HY-12451 FICZ Agonist 99.42% 否
HY-W028393 Indole-3-pyruvic acid Agonist 99.55% 否
HY-19317 ITE Agonist 99.27% 否
HY-W007355 Skatole 99.98% 否
HY-W015273A trans-3-Indoleacrylic acid Inhibitor 99.39% 否
HY-102023 GNF351 Antagonist 99.87% 否
HY-114740 β-Naphthoflavone 99.86% 否
HY-103220 6,2',4'-Trimethoxyflavone Antagonist 98.02% 否
HY-122208 SGA360 Inhibitor 99.93% 否
HY-N1939 Icariside I 99.30% 否
HY-W011338 Benzyl butyl phthalate Activator 97.0% 否
HY-W014502 D-Kynurenine Agonist 99.94% 否
HY-134217 KYN-101 Inhibitor 98.03% 否
HY-141609 IK-175 Inhibitor 99.78% 否
HY-B0845 Prochloraz 99.85% 否
HY-103221 MeBIO 98.0% 否
HY-135750 VAF347 Agonist 99.75% 否
HY-18619 YL-109 Modulator 99.26% 否
HY-119019 ASB14780 Inhibitor 99.83% 否
HY-112628 CAY10464 Antagonist 99.77% 否
HY-144339 AhR agonist 2 99.89% 否
HY-W014075 1-Hydroxypyrene 99.84% 否
HY-112629 PDM2 Antagonist 98.96% 否
HY-12545 Brevetoxin-3 Activator 95.0% 否
HY-N0914 Ajugol 99.61% 否
HY-15001G Stemregenin 1 (GMP) Antagonist / 否
HY-117532 PenCB Inducer 99.94% 否
HY-117102 ANI-7 Activator 99.01% 否
HY-118438 10-Cl-BBQ Agonist 99.48% 否
HY-112627 CAY 10465 Agonist 98.30% 否
HY-130256 β-NF-JQ1 Inhibitor 98.05% 否
HY-111450 CB7993113 Antagonist 98.0% 否
HY-124421 5F-203 Inducer 99.04% 否
HY-D0932 Sudan IV 98.0% 否
HY-135831 AHR antagonist 2 Antagonist 99.30% 否
HY-N4095 Brevifolincarboxylic acid Inhibitor 99.90% 否
HY-W011338S Benzyl butyl phthalate-d4 98.38% 否
HY-77278 25-Hydroxytachysterol3 Agonist 98.89% 否
HY-N0586A Norisoboldine hydrochloride Agonist 99.72% 否
HY-105791 Sulazepam 99.56% 否
HY-111441 1,4-Chrysenequinone Activator 98.42% 否
HY-114682 Lenperone Antagonist 98.11% 否
HY-W718300 Indole-3-pyruvic acid-d5 96.02% 否
HY-W014701 1,4-Dihydroxy-2-naphthoic acid 99.60% 否
HY-103223 Phortress Inducer 98.19% 否
HY-125019 iJak-381 Inhibitor 99.86% 否
HY-17357S Nepafenac-d5 Inhibitor 98.84% 否
HY-34505 1-Methyl-5-pyrazolecarboxylic acid 99.83% 否
HY-W014075S 1-Hydroxypyrene-d9 99.95% 否
HY-W764758 3-OH-Kynurenamine dihydroiodide Activator 99.56% 否
HY-N0586 Norisoboldine Agonist / 否
HY-N10123 Indolokine A5 Agonist 98.0% 否
HY-N2462 Hexachlorobenzene Activator 98.82% 否
HY-N6264 26-Deoxyactein Inhibitor 99.76% 否
HY-RS00483 AHR Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W251708 AHR 10240 / 否
HY-136220 AHR antagonist 5 Antagonist 98.05% 否
HY-100242 Mivotilate Activator 99.58% 否
HY-103222 DiMNF Modulator 98.46% 否
HY-104026CS L-Kynurenine-13C10 sulfate hemihydrate Agonist 99.90% 否
HY-118474 GW 610 Activator 99.78% 否
HY-118780 CHD-5 Antagonist 98.0% 否
HY-16031B AFP464 dihydrochloride Inhibitor 99.67% 否
HY-B0311AS Carbidopa-d3 monohydrate Modulator 98.0% 否
HY-W046846 Corannulene Agonist ≥97.0% 否
HY-W338764 AHR agonist 3 99.79% 否
HY-154825 20-Hydroxyvitamin D3 ≥98.0% 否
HY-B0973 Dibenzothiophene Inhibitor 99.92% 否
HY-N10295 Flavipin Agonist / 否
HY-131340 LASSBio-1632 Inhibitor / 否
HY-136220A AHR antagonist 5 hemimaleate Antagonist / 否
HY-101802 Fluzinamide / 否
HY-104026B L-Kynurenine sulfate Agonist / 否
HY-106487 Pridefine Inhibitor / 否
HY-111157 Dezinamide / 否
HY-114682A Lenperone hydrochloride Antagonist / 否
HY-116148 AHR-11797 / 否
HY-116638 AHR-5333 Inhibitor / 否
HY-116638A AHR-5333 (mandelate) Inhibitor / 否
HY-117774 AHR-2244 hydrochloride / 否
HY-118792 AHR activator 1 / 否
HY-119018 AHR-6293 Inhibitor / 否
HY-119960 AHR-10037 Inhibitor / 否
HY-120377 CYP1A1 inhibitor 8a Inhibitor / 否
HY-120677 AHR-15010 Inhibitor / 否
HY-123432 AHR-13268D Inhibitor / 否
HY-123461 Sul-121 hydrochloride Inhibitor / 否
HY-124021 Benzyl 2-naphthyl ether / 否
HY-125926S 2-Ketodoxapram-d5 / 否
HY-125926S1 2-Ketodoxapram-d4 / 否
HY-129305 Tampramine fumarate Inhibitor / 否
HY-130269 β-Naphthoflavone-CH2-OH / 否
HY-130270 AhR Ligand-Linker Conjugates 1 / 否
HY-130842 β-Naphthoflavone-CH2-Br / 否
HY-135671 AhR modulator-1 / 否
HY-135830 AHR antagonist 4 Antagonist / 否
HY-136891 AHR-16303B / 否
HY-139117 6,2′,4′-Trimethoxyflavone Antagonist / 否
HY-155505 AHR agonist 4 Agonist / 否
HY-156908 3-OH-Kynurenamine Activator / 否
HY-158167 AhR agonist 5 Agonist / 否
HY-158168 AhR agonist 6 Agonist / 否
HY-158169 AhR agonist 7 Agonist / 否
HY-161649 hCYP1B1-IN-2 Inhibitor / 否
HY-168033 AhR agonist 8 Agonist / 否
HY-169753 AHR-IN-1 Inhibitor / 否
HY-17479B Amfenac sodium / 否
HY-175785 X15695 / 否
HY-176771 Tapinarof prodrug-1 / 否
HY-178053 AHR agonist 10 / 否
HY-19826 Isofistularin-3 / 否
HY-A0083C Methacholine iodide Agonist / 否
HY-B0311D Carbidopa hydrochloride Modulator / 否
HY-B0311S1 Carbidopa-d3-1 Modulator / 否
HY-B0678S Metaxalone-d3 98.0% 否
HY-B0678S1 Metaxalone-d6 / 否
HY-B0973S Dibenzothiophene-d8 Inhibitor / 否
HY-N12537A (2R,3S)-PD-1/PD-L1-IN-38 / 否
HY-N16465 Cinnamtannin D1 Inhibitor / 否
HY-W014502R D-Kynurenine (Standard) Agonist / 否
HY-W517076 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin Agonist / 否
HY-W716464 Prochloraz-d7 / 否
HY-101745 Rocastine Antagonist / 否
HY-104026BS L-Kynurenine-13C10 sulfate Agonist / 否
HY-107063 AHR-1911 Activator / 否
HY-109044S Tapinarof-d5 Agonist / 否
HY-118910 AHR-14310C Antagonist / 否
HY-119991 AHR-9294 Inhibitor / 否
HY-128229 AHR antagonist 6 Antagonist / 否
HY-130456 AHR 10718 Inhibitor / 否
HY-163665 AHR antagonist 8 / 否
HY-170514 1,2,3,7,8,9-Hexachlorodibenzofuran Ligand / 否
HY-177563 AhR modulator-2 Activator / 否
HY-D0932S Sudan IV-d6 / 否
HY-RS16533 Ahr Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22964 Ahr Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-U00010 Dazopride / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ahr NCBI NCBI:196
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