2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Stem Cell/Wnt JAK/STAT Signaling
  3. Apoptosis Reactive Oxygen Species (ROS) STAT
  4. Cinnamtannin D1

Cinnamtannin D1 是一种具有口服活性的多酚化合物。Cinnamtannin D1 通过抑制 AHR 表达调节 Th17/Treg 细胞平衡。Cinnamtannin D1 减少 Palmitic acid (PA) (HY-N0830) 诱导的 INS-1 细胞和原代培养小鼠胰岛中的凋亡 (apoptosis) 和 ROS。Cinnamtannin D1 通过下调 p-STAT3/RORγt 减少 Th17 细胞分化，并通过上调 p-STAT5/Foxp3 促进 Treg 细胞分化。Cinnamtannin D1 在胶原诱导的关节炎 (CIA) 小鼠模型中显示出优异的抗关节炎疗效。Cinnamtannin D1 可用于类风湿关节炎 (RA) 研究。

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Cinnamtannin D1

Cinnamtannin D1 Chemical Structure

CAS No. : 97233-06-2

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Cinnamtannin D1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA)[1][2].

体外研究
(In Vitro)

Cinnamtannin D1 (40 μM, 72 h) 显著抑制 BALB/c 小鼠来源的初始 CD4+T 细胞在 Th17 或 Treg 极化条件下的 Th17 细胞分化，并促进 Treg 细胞分化[1]。
Cinnamtannin D1 (40 μM, 72 h) 降低 Th17 细胞上清液中的 IL-17A 水平，并增加 Treg 细胞上清液中的 IL-10 水平[1]。
Cinnamtannin D1 (72 h) 显著抑制 6-formylindolo[3,2-b] carbazole (FICZ) (HY-12451) 诱导的 BALB/c 小鼠脾细胞中的 Th17 细胞分化[1]。
Cinnamtannin D1 (20-40 μM, 96 h) 以剂量依赖方式抑制 BALB/c 小鼠来源的初始 CD4+T 细胞在 Th17 极化条件下的 Th17 细胞分化，并降低 AHR 蛋白表达[1]。
Cinnamtannin D1 (1.56-50 μM, 48 h) 以剂量依赖方式增加 PA 处理的 INS-1 细胞的细胞活力[2]。
Cinnamtannin D1 (25-50 μM, 48 h) 显著降低 PA 诱导的 INS-1 细胞和原代培养小鼠胰岛的凋亡率以及 ROS 和 NO 产生[2]。
Cinnamtannin D1 (25-50 μM, 48 h) 显著降低 INS-1 细胞中 NF-κB 和 c-Jun N-末端激酶 (JNK) 的磷酸化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cinnamtannin D1 相关抗体:

Western Blot Analysis[2]

Cell Line: INS-1 cells
Concentration: 25, 50 μM
Incubation Time: 48 h
Result: Reduced the phosphorylation of NF-κB and c-Jun N-terminal kinase (JNK) in INS-1 cells.
体内研究
(In Vivo)

Cinnamtannin D1 (50 mg/kg，口服，每日，4 周) 在 DBA/1 小鼠胶原诱导的关节炎 (CIA) 模型中显示出优异的抗关节炎疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bovine collagen type II was intradermally injected into the base of the tail of 6-8-week-old male DBA/1 mice for primary immunization[1]
Dosage: 50 mg/kg
Administration: p.o., daily, 4 weeks
Result: Achieved significant alleviation of collagen-induced arthritis (CIA) severity.
Alleviated joint inflammatory cell infiltration and cartilage damage.
Decreased serum levels of CII-specific IgG, IgG2a, IgG3, and inflammatory cytokines (IL-17, IL-6, IL-1β).
Increased serum levels of anti-inflammatory cytokines (IL-10, TGF-β).
reduced the number of IL-17-secreting cells in spleen and draining lymph nodes.
Decreased splenic Th17 cell (CD4+IL-17A+) frequency.
Elevated splenic Treg cell (CD4+CD25+Foxp3+) frequency.
Decreased phospho-STAT3 (Tyr705) expression.
Increased phospho-STAT5 (Tyr649) expression.
Downregulated mRNA levels of Rorc, Il17, Ccr6, Ahr, and Il22.
Upregulated mRNA levels of Foxp3, Il10, and Tgfb.
分子量

864.76

Formula

C45H36O18
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cinnamtannin D1 相关分类

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Keywords:

Cinnamtannin D197233-06-2Cinnamtannin D 1Cinnamtannin D-1ApoptosisReactive Oxygen Species (ROS)STATpancreatic β-cellsapoptosisoxidative stressTh17rheumatoid arthritisInhibitorinhibitorinhibit

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