Sudan IV-d₆  (Synonyms: 苏丹IV-d₆; Solvent Red 24-d₆; C.I. 26105-d₆)

Sudan IV-d₆ (Solvent Red 24-d₆) is the deuterium labeled Sudan IV(HY-D0932). Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections^[1][2][3][4].

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

386.48

C₂₄H₁₄D₆N₄O

1014689-18-9

85-83-6

苏丹IV-d₆

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Refat NA, et al. The induction of cytochrome P450 1A1 by sudan dyes. J Biochem Mol Toxicol. 2008 Mar-Apr;22(2):77-84.  [Content Brief]

  [2]. Lu D, et al. Binding of Sudan II and Sudan IV to bovine serum albumin: comparison studies. Food Chem Toxicol. 2011 Dec;49(12):3158-64.  [Content Brief]

  [3]. Huang ST, et al. An ultrasensitive and selective fluorescence assay for Sudan I and III against the influence of Sudan II and IV. Biosens Bioelectron. 2013 Apr 15;42:136-40.  [Content Brief]

  [4]. Pérez-Sanz F, Riquelme-Pérez M, Martínez-Barba E, de la Peña-Moral J, Salazar Nicolás A, Carpes-Ruiz M, Esteban-Gil A, Legaz-García MDC, Parreño-González MA, Ramírez P, Martínez CM. Efficiency of Machine Learning Algorithms for the Determination of Macrovesicular Steatosis in Frozen Sections Stained with Sudan to Evaluate the Quality of the Graft in Liver Transplantation. Sensors (Basel). 2021 Mar 12;21(6):1993.  [Content Brief]