D-Kynurenine  (Synonyms: D-犬尿氨酸)

D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR)^[1][2][3][4].

D-Kynurenine (10、40、60 和 100 μM) 正向调控肺癌细胞系 95D 的转移，而 siRNAAhr 处理后，95D 细胞的转移能力下降。在 D-Kynurenine (10 和 40 μM) 存在下，检测到 VIM 表达显著增强。10 μM D-Kynurenine 显著降低 E-钙粘蛋白水平。10 μM D-Kynurenine 介导的 VIM 和 E-钙粘蛋白变化在 siRNAAhr 处理下也显著减弱。10/40 μM D-Kynurenine 诱导的 CYP1A1 上调、10 μM D-Kynurenine 诱导的 Ahr 核转移增加、以及 10/40/60/100 μM D-Kynurenine 诱导的 DER 荧光素酶活性增强等证据表明，D-Kynurenine 实际上能够激活 Ahr^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

208.22

C₁₀H₁₂N₂O₃

13441-51-5

固体

Light yellow to yellow

Room temperature in continental US; may vary elsewhere.

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• [1]. Wang XD, et al. A method for the determination of D-kynurenine in biological tissues. Anal Bioanal Chem. 2013 Dec;405(30):9747-54.  [Content Brief]

  [2]. Irukayama-Tomobe Y, et al. Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3930-4.  [Content Brief]

  [3]. Kozaki A, et al. Fluorimetric assay for D-amino acid oxidase activity in rat brain homogenate by using D-kynurenine as a substrate. Biosci Trends. 2012 Oct;6(5):241-7.  [Content Brief]

  [4]. Duan Z, et al. Promoting epithelial-to-mesenchymal transition by D-kynurenine via activating aryl hydrocarbon receptor. Mol Cell Biochem. 2018 Nov;448(1-2):165-173.  [Content Brief]