2. GPCR/G Protein
  3. Adenosine Receptor
  4. Norisoboldine hydrochloride

Norisoboldine hydrochloride  (Synonyms: (+)-Laurelliptine hydrochloride)

目录号: HY-N0586A
产品使用指南

摩尔计算器

Norisoboldine hydrochloride 是一种具有口服活性的天然芳基烃受体 (AhR) 激动剂。Norisoboldine 作为林参中主要的异喹啉类生物碱，可用于类风湿性关节炎和溃疡性结肠炎的研究。

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Norisoboldine hydrochloride Chemical Structure

Norisoboldine hydrochloride Chemical Structure

CAS No. : 5083-84-1

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Other Forms of Norisoboldine hydrochloride:

Norisoboldine hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis[1][2].

IC50 & Target

AhR[2]
体外研究
(In Vitro)

Norisoboldine hydrochloride (1~30 μM; 0~24 hours; CD4+T cells) activates AhR under hypoxic microenvironment and significantly downregulates mRNA expression of miR-31[2].
Norisoboldine hydrochloride (30 μM; 0~24 hours; CD4+T cells) inhibits glycolysis in hypoxia[2].
Norisoboldine hydrochloride (1~30 μM; 0~72 hours; Treg cells) promotes Treg differentiation in hypoxia[2].
Norisoboldine hydrochloride (10, 30 μM) facilitates the disassociation of HSP90/AhR complexes, the nuclear translocation of AhR, and the formation of AhR/ARNT complexes. Norisoboldine hydrochloride induces generation of Treg cells in hypoxia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Norisoboldine hydrochloride 相关抗体:

Western Blot Analysis[2]

Cell Line: CD4+T cells
Concentration: 1~30 μM
Incubation Time: 24 hours
Result: Activated AhR in cells under hypoxic microenvironment.

RT-PCR[2]

Cell Line: CD4+T cells
Concentration: 1~30 μM
Incubation Time: 24 hours
Result: Significantly downregulated mRNA expression of miR-31.

Immunofluorescence[2]

Cell Line: CD4+T cells
Concentration: 30 μM
Incubation Time: 24 hours
Result: Inhibited glycolysis in hypoxia.

Immunofluorescence[2]

Cell Line: Treg cells
Concentration: 1~30 μM
Incubation Time: 72 hours
Result: Promoted Treg differentiation in hypoxia.
体内研究
(In Vivo)

Norisoboldine hydrochloride (10~40 mg/kg; p.o.; 20 days) significantly reduces the severity of joint swelling and erythema during the course of the experiment[1].
Norisoboldine hydrochloride (40 mg/kg; i.g.; 10 days) induces enhancement of CYP1A1 expression and suppresses expressions of Glut1 and HK2 in colons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (18–22 g)
Dosage: 10~40 mg/kg
Administration: P.o.
Result: Significantly reduced the severity of joint swelling and erythema during the course of the experiment.
Animal Model: Female C57BL/6 mice (18–22 g)
Dosage: 40 mg/kg
Administration: I.g.
Result: Induced enhancement of CYP1A1 expression and suppressed expressions of Glut1 and HK2 in colons.
分子量

349.81

Formula

C18H20ClNO4
CAS 号
中文名称

去甲异波尔定（盐酸盐）； 去甲基异波尔定（盐酸盐）； 新木姜子碱（盐酸盐）； 去甲依波而定（盐酸盐）
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Norisoboldine hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Norisoboldine5083-84-1(+)-Laurelliptine去甲异波尔定（盐酸盐） 去甲基异波尔定（盐酸盐） 新木姜子碱（盐酸盐） 去甲依波而定（盐酸盐）Adenosine ReceptorP1 receptororallynaturalisoquinolinealkaloidradixlinderaearthritisUCDSSInhibitorinhibitorinhibit

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目录号：
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