2. Immunology/Inflammation Metabolic Enzyme/Protease Apoptosis
  3. Aryl Hydrocarbon Receptor Cytochrome P450 Apoptosis Interleukin Related
  4. 1,4-Dihydroxy-2-naphthoic acid

1,4-Dihydroxy-2-naphthoic acid 

目录号: HY-W014701 纯度: 99.60%
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1,4-Dihydroxy-2-naphthoic acid 是一种芳烃受体 (AhR) 激动剂。1,4-Dihydroxy-2-naphthoic acid 也是细菌衍生的代谢物，且具有抗炎活性。

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1,4-Dihydroxy-2-naphthoic acid

1,4-Dihydroxy-2-naphthoic acid Chemical Structure

CAS No. : 31519-22-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥110
In-stock
1 g ￥100
In-stock
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10 g   询价  

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Other Forms of 1,4-Dihydroxy-2-naphthoic acid:

1,4-Dihydroxy-2-naphthoic acid 相关抗体

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

1,4-Dihydroxy-2-naphthoic acid is an aryl hydrocarbon receptor (AhR) agonist. 1,4-Dihydroxy-2-naphthoic acid is also a bacterially derived metabolite and has anti-inflammatory activity[1].

体外研究
(In Vitro)

1,4-Dihydroxy-2-naphthoic acid (25-1000 μM, 18-24 h) 在 YAMC 和 Caco2 细胞中诱导 CYP1A1 和 CYP1B1 表达超过 70%[2]。
1,4-Dihydroxy-2-naphthoic acid (100 μM, 24 h) 抑制LPS (HY-D1056 ) 刺激的 RAW264.7 细胞中 IL-1β、IL-6、IL-23p19 和 IL-17A mRNA 水平[4]。
1,4-Dihydroxy-2-naphthoic acid (48-72 h) 抑制 HaCaT、NCTC 2544、Hs-69 和 PIG1 细胞增殖，72 小时IC50 分别为 38.94、46.80、226.3 和 23.98 μM[5]。
1,4-Dihydroxy-2-naphthoic acid (15-120 μM, 9-72 h) 在 HaCaT 细胞中时间和剂量依赖性诱导凋亡和 G0/G1 期阻滞[5]。
1,4-Dihydroxy-2-naphthoic acid (30-240 μM, 24-48 h) 可降低 HaCaT 细胞线粒体膜电位，增加 DNA 断裂，并导致 AIF 和 endoG 核转位[5]。
1,4-Dihydroxy-2-naphthoic acid (20-100 μM, 72 h) 对皮肤刺激性较低，仅在 60 μM 浓度下显著诱导NCTC2544 细胞释放 IL-1α[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1,4-Dihydroxy-2-naphthoic acid 相关抗体:

RT-PCR[2]

Cell Line: YAMC and Caco2 cells
Concentration: 25, 50, 100, 250, 500, 1000 μM
Incubation Time: 18 h
Result: Induced Cyp1a1 and Cyp1b1 in both cells.
Completely eliminated the induction effects on Cyp1a1 and Cyp1b1 when the AhR was knocked out.

Western Blot Analysis[2]

Cell Line: YAMC and Caco2 cells
Concentration: 500 μM
Incubation Time: 24 h
Result: Induced Cyp1a1 and Cyp1b1 expression in both cells.

RT-PCR[4]

Cell Line: LPS-stimulated RAW264.7 cells
Concentration: 100 μM
Incubation Time: 24 h
Result: Inhibited IL-1β, IL-6, IL-23p19 and IL-17A mRNA levels in RAW264.7 cells.

Apoptosis Analysis[5]

Cell Line: HaCaT cells
Concentration: 30, 60 and 120 μM
Incubation Time: 9, 24 and 72 h
Result: Increased in nuclear fluorescence from dark blue to light blue/white (chromatin condensation) at 30 and 60 μM.
Formed apoptotic bodies at 120 μM.
Increased apoptosis ratio time dependently.
Activated Caspase-8 and Caspase-9 and cleavage PARP and Bid.

Apoptosis Analysis[5]

Cell Line: HaCaT cells
Concentration: 15, 30, 60 and 120 μM
Incubation Time: 24 h
Result: Dose-dependently induced G0/G1 cell cycle arrest.
Upregulated p21, while downregulated Cyclin D1/D3 and Cdk4.
体内研究
(In Vivo)

1,4-Dihydroxy-2-naphthoic acid (20 mg/kg, p.o., 共 5-10 周) 成功预防和逆转不可预测性慢性轻度应激(UCMS) 小鼠的快感缺乏样行为[1]。
1,4-Dihydroxy-2-naphthoic acid (2 mg/kg, p.o., 共 14 天) 通过抑制巨噬细胞来源的促炎细胞因子减轻了小鼠结肠炎[4]。
1,4-Dihydroxy-2-naphthoic acid (20 mg/kg, p.o., 共 3 周) 预防了由 MPTP (HY-W114750) 诱导的小鼠运动功能障碍[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: UCMS model established in female C57BL/6 mice (6-7 weeks)[1]
Dosage: 20 mg/kg
Administration: Oral administration (p.o.), once daily, 3 weeks prior to UCMS or 2 weeks after UCMS, for 5-10 weeks
Result: Did not exhibit a reduction in sucrose preference.
Restored the activity of Ca-ATPase and glycogen levels, and reduced phospholipase and lipid peroxides.
Did not significantly affect open field test (OFT), marble bury (MB) and novelty-induced hypophagia (NIH) behaviors.
Had no significant effect on the light/dark (L/D) test or on anxiety behaviors in the elevated plus maze (EPM).
Had a significant effect on spatial learning in unstressed animals.
Animal Model: Colitis model established in 8-week male interleukin-10-deficient mice[4]
Dosage: 2 mg/kg
Administration: Oral administration (p.o.) with water freely available, for 14 days
Result: Significantly reduced the inflammation score.
Significantly reduced F4/80⁺ cells and VCAM-1 expression.
Significantly inhibited IL-1β, IL-6, TNF-α, IL-23p19 and IL-17A mRNA levels.
Animal Model: Parkinson's disease (PD) model established in male C57BL/6 mice[6]
Dosage: 20 mg/kg
Administration: Oral administration (p.o.), for 3 weeks
Result: Prevented MPTP-induced deficits in the motor pole test and in the adhesive strip removal test.
Improved balance beam performance and completely prevented MPTP-induced reduction in stride length.
分子量

204.18

Formula

C11H8O4
CAS 号
性状

固体

颜色

Gray to brown

结构分类
初始来源

Propionibacterium freudenreichii
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 175 mg/mL (857.09 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.8976 mL 24.4882 mL 48.9764 mL
5 mM 0.9795 mL 4.8976 mL 9.7953 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

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由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.60%

COA (290 KB) HNMR (291 KB) LCMS (97 KB)

产品使用指南 (1538 KB)
参考文献

1,4-Dihydroxy-2-naphthoic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8976 mL 24.4882 mL 48.9764 mL 122.4410 mL
5 mM 0.9795 mL 4.8976 mL 9.7953 mL 24.4882 mL
10 mM 0.4898 mL 2.4488 mL 4.8976 mL 12.2441 mL
15 mM 0.3265 mL 1.6325 mL 3.2651 mL 8.1627 mL
20 mM 0.2449 mL 1.2244 mL 2.4488 mL 6.1220 mL
25 mM 0.1959 mL 0.9795 mL 1.9591 mL 4.8976 mL
30 mM 0.1633 mL 0.8163 mL 1.6325 mL 4.0814 mL
40 mM 0.1224 mL 0.6122 mL 1.2244 mL 3.0610 mL
50 mM 0.0980 mL 0.4898 mL 0.9795 mL 2.4488 mL
60 mM 0.0816 mL 0.4081 mL 0.8163 mL 2.0407 mL
80 mM 0.0612 mL 0.3061 mL 0.6122 mL 1.5305 mL
100 mM 0.0490 mL 0.2449 mL 0.4898 mL 1.2244 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,4-Dihydroxy-2-naphthoic acid31519-22-9Aryl Hydrocarbon ReceptorCytochrome P450ApoptosisInterleukin RelatedAhRCYPsIL1,4-DHNACaco2 cellsYAMC cellsInhibitorinhibitorinhibit

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