2. Gene
  3. Bax - BCL2-associated X protein Gene

Bax - BCL2-associated X protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：BCL2 相关X蛋白

种属: Mus musculus

基因 ID: 12028 | 基因类型: protein coding

关于 Bax

Chromosome 7: 45,111,121-45,116,322 reverse strand.GRCm39:CM001000.3

This gene has 6 transcripts (splice variants), 206 orthologues, 10 paralogues and is associated with 27 phenotypes. Ubiquitous expression in ovary adult (RPKM 2.8), placenta adult (RPKM 19.6) and 28 other tissues.

功能概要

该基因编码的蛋白可启动 HSP70 蛋白结合活性；伴侣结合活动；和相同的蛋白质结合活性。参与激活参与细胞凋亡过程的半胱氨酸型内肽酶活性。作用于多个过程的上游或内部，包括动物器官发育；凋亡信号通路；和细胞凋亡过程的调节。位于胞质溶胶中；内质网；和线粒体外膜。 Bax 复合体的一部分。以多种结构表达，包括消化系统；鳃弓;中枢神经系统;泌尿生殖系统；和感觉器官。该基因的人类直系同源物与急性淋巴细胞白血病有关；共济失调毛细血管扩张症;结肠腺癌；结直肠癌；和肺非小细胞癌。与人 Bax 同源（BCL2 相关 X，细胞凋亡调节剂）。 [由基因组资源联盟提供，2022 年 4 月]

Enables HSP70 protein binding activity; chaperone binding activity; and identical protein binding activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and regulation of apoptotic process. Located in cytosol; endoplasmic reticulum; and mitochondrial outer membrane. Part of Bax complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; colorectal cancer; and lung non-small cell carcinoma. Orthologous to human Bax (BCL2 associated X, Apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]

Bax 基因产物(4)

mRNA Protein Name
NM_001411996.1 NP_001398925.1 apoptosis regulator BAX isoform 4
NM_001411994.1 NP_001398923.1 apoptosis regulator BAX isoform 2
NM_007527.4 NP_031553.1 apoptosis regulator BAX isoform 1
NM_001411995.1 NP_001398924.1 apoptosis regulator BAX isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Hsp70 protein binding IDA
IDA: 通过直接分析推断
14752510 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
8631771 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7650488 MGI
enables protein-folding chaperone binding IPI
IPI: 通过物理相互作用推断
14752510 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of B cell apoptotic process IGI
IGI: 通过遗传相互作用推断
11604501 MGI
acts upstream of or within B cell apoptotic process IGI
IGI: 通过遗传相互作用推断
16055554 MGI
acts upstream of or within B cell homeostasis IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within B cell homeostasis IMP
IMP: 通过突变表型推断
16055554 MGI
acts upstream of or within B cell homeostatic proliferation IMP
IMP: 通过突变表型推断
7569956 MGI
acts upstream of or within B cell negative selection IGI
IGI: 通过遗传相互作用推断
16055554 MGI
acts upstream of or within DNA damage response IMP
IMP: 通过突变表型推断
9454845 MGI
acts upstream of or within Sertoli cell proliferation IGI
IGI: 通过遗传相互作用推断
11784036 MGI
acts upstream of or within T cell homeostatic proliferation IMP
IMP: 通过突变表型推断
7569956 MGI
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
16735463 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IGI
IGI: 通过遗传相互作用推断
12847083 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
14502238 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IDA
IDA: 通过直接分析推断
9560217 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IMP
IMP: 通过突变表型推断
11836241 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
IMP: 通过突变表型推断
10479688 MGI
acts upstream of or within apoptotic mitochondrial changes IDA
IDA: 通过直接分析推断
12925707 MGI
acts upstream of or within apoptotic process IDA
IDA: 通过直接分析推断
9560217 MGI
acts upstream of apoptotic process IGI
IGI: 通过遗传相互作用推断
17107997 MGI
acts upstream of apoptotic process IMP
IMP: 通过突变表型推断
9988273 MGI
acts upstream of or within apoptotic process IMP
IMP: 通过突变表型推断
10201940 MGI
acts upstream of or within apoptotic process involved in blood vessel morphogenesis IGI
IGI: 通过遗传相互作用推断
15955981 MGI
acts upstream of or within apoptotic process involved in embryonic digit morphogenesis IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of apoptotic process involved in mammary gland involution IMP
IMP: 通过突变表型推断
10363969 MGI
acts upstream of apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
18436203 MGI
acts upstream of or within apoptotic signaling pathway IMP
IMP: 通过突变表型推断
12925707 MGI
acts upstream of or within blood vessel remodeling IGI
IGI: 通过遗传相互作用推断
15955981 MGI
acts upstream of calcium ion transport into cytosol IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of or within cell population proliferation IGI
IGI: 通过遗传相互作用推断
10762311 MGI
acts upstream of or within cellular response to UV IGI
IGI: 通过遗传相互作用推断
14963330 MGI
acts upstream of or within cerebral cortex development IMP
IMP: 通过突变表型推断
15342910 MGI
acts upstream of or within development of secondary sexual characteristics IMP
IMP: 通过突变表型推断
15944391 MGI
acts upstream of or within ectopic germ cell programmed cell death IGI
IGI: 通过遗传相互作用推断
14660547 MGI
acts upstream of ectopic germ cell programmed cell death IMP
IMP: 通过突变表型推断
9988273 MGI
acts upstream of or within ectopic germ cell programmed cell death IMP
IMP: 通过突变表型推断
14660547 MGI
acts upstream of epithelial cell apoptotic process IMP
IMP: 通过突变表型推断
9988273 MGI
acts upstream of or within epithelial cell proliferation IDA
IDA: 通过直接分析推断
9176392 MGI
acts upstream of establishment of localization in cell IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of establishment of localization in cell IMP
IMP: 通过突变表型推断
15947791 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IGI
IGI: 通过遗传相互作用推断
15680329 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: 通过直接分析推断
10597216 MGI
acts upstream of or within fertilization IGI
IGI: 通过遗传相互作用推断
10894153 MGI
acts upstream of or within germ cell development IGI
IGI: 通过遗传相互作用推断
10894153 MGI
acts upstream of or within glycosphingolipid metabolic process IMP
IMP: 通过突变表型推断
18308723 MGI
acts upstream of or within homeostasis of number of cells IGI
IGI: 通过遗传相互作用推断
11163212 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: 通过突变表型推断
10931486 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: 通过突变表型推断
11413548 MGI
acts upstream of or within hypothalamus development IMP
IMP: 通过突变表型推断
15342910 MGI
acts upstream of intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
14502238 MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: 通过突变表型推断
10479688 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IGI
IGI: 通过遗传相互作用推断
15901672 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
12952892 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IGI
IGI: 通过遗传相互作用推断
12847083 MGI
acts upstream of or within kidney development IGI
IGI: 通过遗传相互作用推断
9241272 MGI
acts upstream of or within leukocyte homeostasis IGI
IGI: 通过遗传相互作用推断
11163212 MGI
acts upstream of or within limb morphogenesis IGI
IGI: 通过遗传相互作用推断
11163212 MGI
acts upstream of or within male gonad development IGI
IGI: 通过遗传相互作用推断
9241272 MGI
acts upstream of or within male gonad development IMP
IMP: 通过突变表型推断
16270031 MGI
acts upstream of or within mitochondrial fusion IGI
IGI: 通过遗传相互作用推断
16893972 MGI
acts upstream of or within mitochondrion organization IGI
IGI: 通过遗传相互作用推断
20671748 MGI
acts upstream of motor neuron apoptotic process IMP
IMP: 通过突变表型推断
15944391 MGI
acts upstream of or within motor neuron apoptotic process IMP
IMP: 通过突变表型推断
12917363 MGI
acts upstream of or within myeloid cell homeostasis IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within negative regulation of apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
18436203 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
10762311 MGI
acts upstream of or within negative regulation of endoplasmic reticulum calcium ion concentration IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
12952892 MGI
acts upstream of or within negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
8625820 MGI
acts upstream of or within negative regulation of peptidyl-serine phosphorylation IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of or within nervous system development IMP
IMP: 通过突变表型推断
12810599 MGI
acts upstream of neuron apoptotic process IDA
IDA: 通过直接分析推断
8625820 MGI
acts upstream of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
9096145 MGI
acts upstream of or within neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
10762311 MGI
acts upstream of neuron apoptotic process IMP
IMP: 通过突变表型推断
9699561 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: 通过突变表型推断
10479688 MGI
acts upstream of or within neuron migration IMP
IMP: 通过突变表型推断
15590937 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within ovarian follicle development IGI
IGI: 通过遗传相互作用推断
10894153 MGI
acts upstream of or within ovarian follicle development IMP
IMP: 通过突变表型推断
17244737 MGI
acts upstream of peptidyl-serine phosphorylation IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of or within positive regulation of B cell apoptotic process IGI
IGI: 通过遗传相互作用推断
11604501 MGI
acts upstream of or within positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
15753097 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: 通过遗传相互作用推断
8798452 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
9241272 MGI
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
26949185 MGI
acts upstream of or within positive regulation of apoptotic process involved in mammary gland involution IMP
IMP: 通过突变表型推断
10363969 MGI
acts upstream of or within positive regulation of calcium ion transport into cytosol IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of or within positive regulation of developmental pigmentation IGI
IGI: 通过遗传相互作用推断
9241272 MGI
acts upstream of or within positive regulation of developmental process IMP
IMP: 通过突变表型推断
9988273 MGI
acts upstream of or within positive regulation of epithelial cell apoptotic process IMP
IMP: 通过突变表型推断
9988273 MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
14502238 MGI
acts upstream of or within positive regulation of mitochondrial membrane permeability involved in apoptotic process IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within positive regulation of motor neuron apoptotic process IMP
IMP: 通过突变表型推断
15944391 MGI
acts upstream of or within positive regulation of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
9096145 MGI
acts upstream of or within positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
8816704 MGI
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
27098698 MGI
acts upstream of or within positive regulation of release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
15947791 MGI
acts upstream of or within positive regulation of reproductive process IMP
IMP: 通过突变表型推断
9988273 MGI
acts upstream of or within post-embryonic camera-type eye morphogenesis IGI
IGI: 通过遗传相互作用推断
15955981 MGI
acts upstream of or within post-embryonic development IGI
IGI: 通过遗传相互作用推断
9241272 MGI
acts upstream of or within protein insertion into mitochondrial membrane IMP
IMP: 通过突变表型推断
12952892 MGI
involved in regulation of apoptotic process IMP
IMP: 通过突变表型推断
33712461 MGI
acts upstream of or within regulation of cell cycle IGI
IGI: 通过遗传相互作用推断
16055554 MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
14507967 MGI
acts upstream of or within regulation of mammary gland epithelial cell proliferation IMP
IMP: 通过突变表型推断
10363969 MGI
acts upstream of or within regulation of mitochondrial membrane permeability involved in apoptotic process IGI
IGI: 通过遗传相互作用推断
14963330 MGI
acts upstream of or within regulation of mitochondrial membrane permeability involved in programmed necrotic cell death IMP
IMP: 通过突变表型推断
22493254 MGI
NOT acts upstream of or within regulation of mitochondrial membrane potential IDA
IDA: 通过直接分析推断
14614769 MGI
acts upstream of or within regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
19029045 MGI
acts upstream of or within regulation of nitrogen utilization IGI
IGI: 通过遗传相互作用推断
9241272 MGI
acts upstream of or within release of cytochrome c from mitochondria IDA
IDA: 通过直接分析推断
9560217 MGI
acts upstream of or within release of cytochrome c from mitochondria IGI
IGI: 通过遗传相互作用推断
14963330 MGI
acts upstream of release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
15947791 MGI
acts upstream of or within response to axon injury IMP
IMP: 通过突变表型推断
16103918 MGI
acts upstream of or within response to gamma radiation IMP
IMP: 通过突变表型推断
17068116 MGI
acts upstream of or within response to ionizing radiation IGI
IGI: 通过遗传相互作用推断
10639175 MGI
acts upstream of or within response to ionizing radiation IMP
IMP: 通过突变表型推断
15578100 MGI
acts upstream of or within response to salt stress IGI
IGI: 通过遗传相互作用推断
16571598 MGI
acts upstream of or within response to toxic substance IMP
IMP: 通过突变表型推断
9454845 MGI
acts upstream of or within response to wounding IMP
IMP: 通过突变表型推断
14507967 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: 通过突变表型推断
9699561 MGI
acts upstream of or within retinal cell programmed cell death IMP
IMP: 通过突变表型推断
14517994 MGI
acts upstream of or within sex differentiation IMP
IMP: 通过突变表型推断
15342910 MGI
acts upstream of or within spermatid differentiation IMP
IMP: 通过突变表型推断
16270031 MGI
acts upstream of or within spermatogenesis IGI
IGI: 通过遗传相互作用推断
10894153 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
7569956 MGI
acts upstream of or within thymocyte apoptotic process IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within vagina development IGI
IGI: 通过遗传相互作用推断
11163212 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of BAX complex IPI
IPI: 通过物理相互作用推断
11060313 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
10464378 MGI
located in cytosol IDA
IDA: 通过直接分析推断
9553144 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
12847083 MGI
located in intracellular anatomical structure IDA
IDA: 通过直接分析推断
9008714 MGI
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
11369777 MGI
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
12910269 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
11369777 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Bax 蛋白结构

bcl-2

bcl-2: TIGR00865 (4 - 191)

  • 0
  • 100
  • 192 a.a.
蛋白主名 其他名称

apoptosis regulator BAX

相关产品

Approval
生物活性分子 (6)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B1192 Estradiol benzoate 99.90% 否
HY-B0402 Amantadine Modulator 99.90% 否
HY-B1357 Digitoxin 99.22% 是
HY-B0402A Amantadine hydrochloride Modulator ≥98.0% 是
HY-B0621 Triclabendazole 99.36% 是
HY-B0402B Amantadine sulfate Modulator / 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-13755 Sulforaphane Inhibitor 99.75% Phase 4
HY-13560 AVN-944 Modulator 99.89% Phase 2
HY-168739 Topoisomerase I inhibitor 17 Activator / Phase 2
Pre-clinical Phase
生物活性分子 (74)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-107202 Polyinosinic-polycytidylic acid 99.40% 否
HY-N0171A Beta-Sitosterol (purity>98%) 99.74% 否
HY-13594 Chlorin e6 98.49% 否
HY-103269 BAI1 Inhibitor 99.89% 否
HY-107202A Poly (I:C):Kanamycin (1:1) 51.00% 否
HY-N0674 Dehydrocorydaline Modulator 99.77% 否
HY-P0081 Bax inhibitor peptide V5 Inhibitor 99.90% 否
HY-N0361 Dihydrocapsaicin Modulator 99.93% 否
HY-W250111 Carboxymethyl chitosan Activator / 否
HY-120079 MSN-125 Inhibitor 99.00% 否
HY-B1971 Deltamethrin 99.93% 否
HY-123054 BTSA1 Activator 99.77% 否
HY-P1928 Humanin Inhibitor 99.83% 否
HY-13755A (R)-Sulforaphane Inhibitor 99.48% 否
HY-N0060B (E)-Ferulic acid Activator 99.89% 否
HY-N6626 Pyraclostrobin 99.91% 否
HY-N0831 Jaceosidin Activator 99.51% 否
HY-13108 Bz 423 Activator 99.72% 否
HY-118948 MSN-50 Inhibitor 98.68% 否
HY-W082785A L6H21 Modulator 99.19% 否
HY-101310 SYM 2081 Activator ≥98.0% 否
HY-126437 Poly-L-lysine hydrobromide (MW 30000-70000) Inhibitor / 否
HY-157176 BAX-IN-1 Inhibitor 98.05% 否
HY-N2067 Vanillyl alcohol 99.68% 否
HY-N0905 Ginsenoside Rh4 Activator 99.28% 否
HY-15341 BAM7 Activator 98.53% 否
HY-132173 GL0388 Activator 98.01% 否
HY-108164 Aspidin BB Modulator 98.08% 否
HY-122760 Bax activator-1 Activator 98.45% 否
HY-N1157 Thevetiaflavone Modulator 98.02% 否
HY-147889 BBR-BODIPY Activator 98.15% 否
HY-146548 Anticancer agent 43 Inducer 98.58% 否
HY-161659 Apoptosis inducer 19 Modulator 98.31% 否
HY-N9802 n-Butyl-β-D-fructofuranoside Activator ≥97.0% 否
HY-147929 Apoptotic agent-3 Activator / 否
HY-174469 PROTAC PI3K/110β degrader-2 Inhibitor / 否
HY-143235 BRD4 Inhibitor-15 Modulator / 否
HY-168877 FMP / 否
HY-N12999 Stigmast-5-en-3-ol / 否
HY-162360 EGFR-IN-109 Inhibitor / 否
HY-P10993 CT20p / 否
HY-101996 SMBA1 Agonist / 否
HY-148368 CYD-4-61 Activator / 否
HY-168623 EGFR-IN-134 Inhibitor / 否
HY-175037 DNH28 Inhibitor / 否
HY-N10313 Dehydrobruceine B Modulator / 否
HY-170912 Topo I/II-IN-2 / 否
HY-147514 Anticancer agent 64 Modulator / 否
HY-175019 VEGFR-2-IN-70 Agonist / 否
HY-151429 Antitumor agent-77 Inhibitor / 否
HY-P10992 YVPGP Modulator / 否
HY-175020 QNX-10 / 否
HY-146253 CDK1/2/4-IN-1 Activator / 否
HY-P3148 Astin B Modulator / 否
HY-N0831R Jaceosidin (Standard) Activator / 否
HY-174855 PI3K/mTOR-IN-17 Inhibitor / 否
HY-144792 Bcl-2-IN-7 Modulator / 否
HY-144791 Bcl-2-IN-6 Modulator / 否
HY-117652 Lobetyol Modulator / 否
HY-174419 TFSeB Activator / 否
HY-146105 Anticancer agent 65 Modulator / 否
HY-170929 EMT inhibitor-3 / 否
HY-147928 Apoptotic agent-2 Activator / 否
HY-175332 Apoptosis inducer 43 Inhibitor / 否
HY-175021 HDAC-IN-91 Inhibitor / 否
HY-150540 Bcl-2-IN-10 Inhibitor / 否
HY-149517 EGFR/BRAFV600E-IN-2 Activator / 否
HY-151428 Antitumor agent-78 Inhibitor / 否
HY-175227 STAT3/NF-κB-IN-1 Inhibitor / 否
HY-172886 PI3K-IN-58 Modulator / 否
HY-126311 4-Hydroxyresveratrol Inducer / 否
HY-119682 Bax agonist 1 / 否
HY-122481 Thaspine acetate / 否
HY-N8508 Myrothecine A Inducer / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bax NCBI NCBI:581
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