2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis Caspase PARP Bcl-2 Family
  4. Anticancer agent 64

Anticancer agent 64 (化合物 5m) 对 CCRF-CEM 细胞具有细胞毒性，其 IC50 为2.4 μM。Anticancer agent 64 通过诱导细胞凋亡表现出良好的抗癌活性。Anticancer agent 64 诱导 caspase 3 和 7 的激活和 PARP 的裂解。Anticancer agent 64 具有明显的线粒体去极化作用。

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Anticancer agent 64 Chemical Structure

Anticancer agent 64 Chemical Structure

CAS No. : 2387902-92-1

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Anticancer agent 64 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC50 of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization[1].

IC50 & Target

Caspase 3

 

Caspase-7

 

Bcl-2

 

Bax

 

PARP

 

体外研究
(In Vitro)

Anticancer agent 64 (compound 5m) increases BAX expression and decreases Bcl-2 protein expression[1].
. Anticancer agent 64 shows significant increasement in cells accumulation in the G2/M phase of the cell cycle, while proportion of cells in S phase is reduced[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 64 相关抗体:
分子量

510.77

Formula

C31H46N2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 64 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 642387902-92-1Anticancer agent64Anticancer agent-64ApoptosisCaspasePARPBcl-2 Familypoly ADP ribose polymerasefibroblastslow toxicityCCRF-CEM cellsTriterpeneHeterocycleThiazoleCytotoxicityCaspase assayanticancerbiological activityInhibitorinhibitorinhibit

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