2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. Apoptosis EGFR Caspase Bcl-2 Family
  4. EGFR-IN-109

EGFR-IN-109 (compound 4) 是一个 EGFR 抑制剂，对 EGFRWT 和 EGFRT790M 的 IC50 值分别为 25.8 和 182.3 nM。EGFR-IN-109 能够在 G2/M 期阻止癌细胞的生长并诱导早期和晚期细胞凋亡。EGFR-IN-109 可用于癌症研究。

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EGFR-IN-109 Chemical Structure

EGFR-IN-109 Chemical Structure

CAS No. : 3019971-97-9

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EGFR-IN-109 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-109 (compound 4) is an EGFR inhibitor, with the IC50 values of 25.8 and 182.3 nM for EGFRWT and EGFRT790M, respectively. EGFR-IN-109 arrests the cancer cells’ growth at the G2/M phase and induces both early and late apoptosis. EGFR-IN-109 can be used in cancer research[1].

IC50 & Target

EGFR

25.8 nM (IC50)

EGFRT790M

182.3 nM (IC50)

Caspase-3

 

Caspase-9

 

Bax

 

Bcl-2

 

体外研究
(In Vitro)

EGFR-IN-109 (compound 4) (0-20 μM, 2 days) 抑制高表达 EGFR 细胞 MCF-7 和 A549 的增殖，IC50 值分别为 13.06 和 20.13 μM[1]。
EGFR-IN-109 (13.06 μM, 24 h) 通过将细胞生长阻滞在 G2/M 期促进 A549 细胞凋亡[1]。
EGFR-IN-109 (13.06 μM, 72 h) 促进 A549 细胞中的 caspase-3、caspase-9 和 BAX 的蛋白表达，下调 Bcl-2 的蛋白表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-109 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7, A549, the normal cell lines W138 cell
Concentration: 0-20 μM
Incubation Time: 2 days
Result: Showed obvious inhibitory effect on MCF-7 and A549, and weak inhibitory effect on WI-38 cell line, with the selectivity index of 2.8 and 1.8 for the two cancer cell lines, respectively.
分子量

264.35

Formula

C12H16N4OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-109 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-1093019971-97-9ApoptosisEGFRCaspaseBcl-2 FamilyEpidermal growth factor receptorErbB-1HER1ProliferationCell cycleSafety assayW138 cellA549 cellMCF7 cellHepG-2 cellInhibitorinhibitorinhibit

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