2. Apoptosis Epigenetics Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Apoptosis Bcl-2 Family Caspase MDM-2/p53 PARP Amylases
  4. Stigmast-5-en-3-ol

Stigmast-5-en-3-ol 诱导癌细胞凋亡 (apoptosis) 和抑制增殖通过增加 Bax、Caspase-9、p53 和 PARP 裂解的产生，降低 Bcl-xl 表达。Stigmast-5-en-3-ol 对葡萄糖淀粉酶和 α-淀粉酶 (α-amylase) 表现出强效抑制活性，具有较高的抗氧化活性。Stigmast-5-en-3-ol 可用于白血病、乳腺癌、2 型糖尿病、肥胖症等疾病的研究。

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Stigmast-5-en-3-ol

Stigmast-5-en-3-ol Chemical Structure

CAS No. : 5779-62-4

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Stigmast-5-en-3-ol 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 PARP 亚型特异性产品:

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Stigmast-5-en-3-ol induces cancer cell apoptosis and inhibits proliferation by increasing the production of Bax, Caspase-9, p53, and PARP cleavage and reducing Bcl-xl expression. Stigmast-5-en-3-ol exhibits potent inhibitory activity against glucoamylase and α-amylase and possesses high antioxidant activity. Stigmast-5-en-3-ol can be used in the research of diseases such as leukemia, breast cancer, type 2 diabetes, and obesity[1][2][3].

IC50 & Target[1]

Caspase-9

 

Bax

 

Bcl-xL

 

体外研究
(In Vitro)

Stigmast-5-en-3-ol (Compound DGEH21-3-2) (12.5-50 μg/mL, 24 小时) 对 HL-60 和 MCF-7 细胞有细胞毒作用，IC50 分别为 37.82 和 45.17 μg/mL[1]。
Stigmast-5-en-3-ol (12.5-50 μg/mL, 24 小时) 诱导 HL-60 和 MCF-7 细胞凋亡，增加 DNA 损伤，增加 Bax、Caspase-9、p53 和 PARP 裂解的产生，并降低 Bcl-xl 水平[1]。
Stigmast-5-en-3-ol (Compound 24R) (2-10 μg/mL, 30 分钟) 表现出强效抑制活性对葡萄糖淀粉酶和 α-淀粉酶，IC50 分别为 5.8 和 7.198 µg/mL，表现出很高的自由基活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Stigmast-5-en-3-ol 相关抗体:

Apoptosis[1]

Cell Line: HL-60 and MCF-7 cells
Concentration: 12.5, 25, 50 μg/mL
Incubation Time: 24 h
Result: Increased the number of apoptotic bodies and dose-dependently increased the sub-G1 apoptotic cell population, resulting in a sub-G1 apoptotic cell population of 66.30% in HL-60 cells and 60.05% in MCF-7 cells at 50 μg/ml.
Increased production of Bax, Caspase-9, and PARP cleavage, and decreased Bcl-xl levels.
Dose-dependent increased p53 expression in MCF-7 cells.
分子量

414.71

Formula

C29H50O
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Stigmast-5-en-3-ol 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stigmast-5-en-3-ol5779-62-4ApoptosisBcl-2 FamilyCaspaseMDM-2/p53PARPAmylasespoly ADP ribose polymeraseHL-60 cellsMCF-7 cellsleukemiabreast cancertype 2 diabetesobesityInhibitorinhibitorinhibit

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