Ezh2 - enhancer of zeste 2 polycomb repressive complex 2 subunit Gene

中文名称：zeste 2 多梳抑制复合物 2 亚基的增强子

种属: Mus musculus

同用名: KMT6; Enx-1; Enx1h; mKIAA4065

关于 Ezh2

功能概要

该基因编码的蛋白可启动多种功能，包括核酸结合活性；蛋白质甲基转移酶活性；和转录辅阻遏物活性。参与B细胞分化；细胞发育；和昼夜节律的调节。作用于几个过程的上游或内部，包括大分子甲基化；细胞分化的负调控；和转录调控，DNA 模板化。位于中心异染色质和原核中。 ESC/E(Z) 复合物和染色质沉默复合物的一部分。以多种结构表达，包括消化系统；中枢神经系统;早孕;泌尿生殖系统；和外皮系统。用于研究B细胞淋巴瘤；韦弗综合症；和急性淋巴细胞白血病。该基因的人类直系同源物与韦弗综合征有关；骨癌（多发性）；胃肠系统癌症（多发性）；血液系统癌症（多发性）；和肺癌。与人类 EZH2 同源（zeste 2 多梳抑制复合物 2 亚基的增强子）。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including nucleic acid binding activity; protein methyltransferase activity; and transcription corepressor activity. Involved in B cell differentiation; cell development; and regulation of circadian rhythm. Acts upstream of or within several processes, including macromolecule methylation; negative regulation of cell differentiation; and regulation of transcription, DNA-templated. Located in pericentric heterochromatin and pronucleus. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in Weaver syndrome; bone Cancer (multiple); gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); and lung Cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]