2. Cell Cycle/DNA Damage Stem Cell/Wnt PI3K/Akt/mTOR
  3. CDK GSK-3
  4. Indirubin-5-sulfonate

Indirubin-5-sulfonate 是周期蛋白依赖性激酶(CDK) 的抑制剂，对CDK1/cyclin B、CDK2/cyclin A、CDK2/cyclin E、CDK4/cyclin D1 和CDK5/p35 的IC50 值分别为55 nM、35 nM、150 nM、300 nM 和 65 nM。Indirubin-5-sulfonate 同样能抑制GSK-3β 的活性。

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Indirubin-5-sulfonate Chemical Structure

Indirubin-5-sulfonate Chemical Structure

CAS No. : 244021-67-8

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Indirubin-5-sulfonate 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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GSK-3 GSK-3α GSK-3β

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively[1]. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β[2].

IC50 & Target[1]

Cdk1/cyclin B

55 nM (IC50)

cdk2/cyclin A

35 nM (IC50)

CDK2/cyclinE

150 nM (IC50)

Cdk4/cyclin D1

300 nM (IC50)

CDK5/p35

65 nM (IC50)

GSK-3β

 

分子量

342.33

Formula

C16H10N2O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Indirubin-5-sulfonate 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Indirubin-5-sulfonate244021-67-8CDKGSK-3Cyclin dependent kinaseGlycogen synthase kinase-3Glycogen synthase kinase 3Inhibitorinhibitorinhibit

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