2. PI3K/Akt/mTOR Stem Cell/Wnt Cell Cycle/DNA Damage
  3. GSK-3 CDK
  4. (E/Z)-BIO-acetoxime

(E/Z)-BIO-acetoxime  (Synonyms: GSK-​3 Inhibitor X)

目录号: HY-114903
产品使用指南

摩尔计算器

(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) 是一种有效的选择性 GSK-3α/β 抑制剂，IC50 为 10 nM。(E/Z)-BIO-acetoxime 对 GSK-3α/β 具有超过 CDK5/p25，CDK2/cyclin A 和 CDK1/cyclin B (IC50=2.4, 4.3, 63 μM) 200 倍的选择性。

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(E/Z)-BIO-acetoxime Chemical Structure

(E/Z)-BIO-acetoxime Chemical Structure

CAS No. : 740841-15-0

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规格 价格 是否有货 数量
1 mg ￥670
3 - 4 周
5 mg
询价
10 mg
询价

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Customer Review

Other Forms of (E/Z)-BIO-acetoxime:

(E/Z)-BIO-acetoxime 相关抗体

Top Publications Citing Use of Products

查看 GSK-3 亚型特异性产品:

查看所有亚型
GSK-3 GSK-3α GSK-3β

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM)[1].

IC50 & Target[1]

GSK-3α

10 nM (IC50)

GSK-3β

10 nM (IC50)

Cdk5/p25

2.4 μM (IC50)

CDK2/cyclinA

4.3 μM (IC50)

CDK1/cyclinB

63 μM (IC50)

体外研究
(In Vitro)

E/Z)-BIO-acetoxime (compound 13) shows more than 200-flod selectivity for GSK-3α/β over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, with IC50s of 0.01, 2.4, 4.3 and 63 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(E/Z)-BIO-acetoxime 相关抗体:
分子量

398.21

Formula

C18H12BrN3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(E/Z)-BIO-acetoxime 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-BIO-acetoxime740841-15-0GSK-​3 Inhibitor XGSK-3CDKGlycogen synthase kinase-3Glycogen synthase kinase 3Cyclin dependent kinaseInhibitorinhibitorinhibit

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