2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Neuronal Signaling Cell Cycle/DNA Damage PI3K/Akt/mTOR Stem Cell/Wnt Apoptosis
  3. EGFR VEGFR Trk Receptor CDK FAK Akt GSK-3 Apoptosis Caspase Bcl-2 Family
  4. Multi-kinase-IN-7

Multi-kinase-IN-7 是一种多激酶抑制剂，其对 EGFR、VEGFR2、TrKA 和 CDK2 的 IC50 分别为 2.19、2.95、3.59 和 9.31 μM。Multi-kinase-IN-7 对 FAK、AKT1、GSK3β 和 CDK5 表现出中等和较弱的活性，IC50 值分别为 6.3、9.2、11.7 和 23.4 μM。Multi-kinase-IN-7 对 NCI 癌细胞系表现出广谱抗增殖潜力。Multi-kinase-IN-7 可诱导细胞周期停滞、细胞凋亡 (apoptosis) 和坏死。MDA-MB-231 可用于乳腺癌的研究。

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Multi-kinase-IN-7

Multi-kinase-IN-7 Chemical Structure

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Multi-kinase-IN-7 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

查看 Trk Receptor 亚型特异性产品:

查看所有亚型
TrkA TrkB TrkC Trk

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 GSK-3 亚型特异性产品:

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GSK-3 GSK-3α GSK-3β

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Multi-kinase-IN-7 is a multikinase inhibitor with IC50s of 2.19, 2.95, 3.59 and 9.31 μM against EGFR, VEGFR2, TrKA and CDK2, respectively. Multi-kinase-IN-7 shows moderate and weaker activity against FAK, AKT1, GSK3β and CDK5 with IC50 values of 6.3, 9.2, 11.7 and 23.4 μM, respectively. Multi-kinase-IN-7 displays broad spectrum anti­proliferative potential against NCI cancer cell lines. Multi-kinase-IN-7 induces cell cycle arrest, apoptosis and necrosis. Multi-kinase-IN-7 Inhibitor can be used for the study of breast cancer[1].

IC50 & Target[1]

EGFR

2.19 μM (IC50)

VEGFR-2

2.95 μM (IC50)

TrkA

3.59 μM (IC50)

CDK2

9.31 μM (IC50)

CDK5

23.4 μM (IC50)

Akt1

9.2 μM (IC50)

GSK3β

11.7 μM (IC50)

Caspase 3

 

Bax

 

Bcl-2

 

体外研究
(In Vitro)

Multi-kinase-IN-7 (Compound 12b) (0.01-100 μM, 24 h) 对 NCI 癌细胞系表现出广谱抗增殖潜力，GI50 平均值为 10.63 μM，并且对所有乳腺癌细胞系表现出强大的抗增殖活性，GI50 范围为 4.03-15.3 μM[1]。
Multi-kinase-IN-7 (15.3 μM, 48 h) 将 MDA-MB-231 细胞的细胞周期阻滞在 G2/M 期，并显著诱导细胞凋亡 (通过线粒体途径) 和坏死[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Multi-kinase-IN-7 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 15.3 μM
Incubation Time: 48 h
Result: Inhibited proliferation by blocking the G2/M phase.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 15.3 μM
Incubation Time: 48 h
Result: Significantly induced apoptosis and necrosis, which are the main forms of cell death.
Increased activated Caspase-3 and Bax, and decreased Bcl-2.
分子量

393.24

Formula

C18H13BrN6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Multi-kinase-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-kinase-IN-7EGFRVEGFRTrk ReceptorCDKFAKAktGSK-3ApoptosisCaspaseBcl-2 FamilyEpidermal growth factor receptorErbB-1HER1Vascular endothelial growth factor receptorTropomyosin related kinase receptor Cyclin dependent kinasePTK2 protein tyrosine kinase 2PTK2Focal adhesion kinasePKBProtein kinase BGlycogen synthase kinase-3Glycogen synthase kinase 3Triazolo[1,5-a]pyrimidinesMultikinase inhibitorsSynthesisTrKACDK2VEGFR2Inhibitorinhibitorinhibit

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