2. PI3K/Akt/mTOR Stem Cell/Wnt Cell Cycle/DNA Damage Anti-infection Membrane Transporter/Ion Channel Autophagy
  3. GSK-3 CDK Parasite Proton Pump HSV Autophagy
  4. Manzamine A

Manzamine A  (Synonyms: Keramamine A)

目录号: HY-117025
产品使用指南

摩尔计算器

Manzamine A 是一种口服活性 β-carboline 生物碱，抑制 GSK-3β 和 CDK-5 的 IC50 值为 10.2 μM 和 1.5 μM。Manzamine A 靶向胰腺癌细胞的 vacuolar ATPases 并抑制自噬 (autophagy)。Manzamine A 具有抗疟和抗癌活性。Manzamine A 对 HSV-1 具有较强的活性。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Manzamine A hydrochloride 通常具有更好的水溶性和稳定性。

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Manzamine A Chemical Structure

Manzamine A Chemical Structure

CAS No. : 104196-68-1

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规格 是否有货
1 mg
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5 mg
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10 mg
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500 μg
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Customer Review

Other Forms of Manzamine A:

Manzamine A 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

Cell Viability Assay
Proliferation Assay

    Manzamine A purchased from MCE. Usage Cited in: Mar Drugs. 2023, 21(3), 151.

    Manzamine A (MA) shows a long-term ability to inhibit both MCF-7 and MDA-MB-231 cells growth. The MA (0, 2, 4 μM; 24 h)-treated cells are seeded in 6-well plates and then cultured for 2 weeks.

    Manzamine A purchased from MCE. Usage Cited in: Mar Drugs. 2023, 21(3), 151.

    Manzamine A (MA; 0, 0.5, 1, 2, 4, 8 μM; 24 h) shows cytotoxic effects on MDA-MB-231 and MCF-7 cells but is non-toxic to normal breast epithelial MCF-10A cells in a dose-dependent manner.

    查看 GSK-3 亚型特异性产品:

    查看所有亚型
    GSK-3 GSK-3α GSK-3β

    查看 CDK 亚型特异性产品:

    查看所有亚型
    CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

    查看 Parasite 亚型特异性产品:

    查看所有亚型
    Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1[1][2][3][4].

    IC50 & Target[1][2][3]

    Plasmodium

     

    GSK-3β

    10.2 μM (IC50)

    CDK5

    1.5 μM (IC50)

    vacuolar ATPases

     

    Malaria

     

    HSV-1

     

    体外研究
    (In Vitro)

    Manzamine A (5-50 µM, 18 h) decreases tau phosphorylation, measured with ELISA[1].
    Manzamine A (10 µM) inhibits yeast S. cerevisiae growth by 30%[2].
    Manzamine A displays a few enlarged vacuoles in yeast[2].
    Manzamine A (2.5-10 µM, 24 h) increases acidity in pancreatic cancer cells and non-malignant Vero cells[2].
    Manzamine A (1 µM, 24 h) inhibits HSV-1 infection in SIRC cells[4].
    Manzamine A shows antimalarial activity with an IC50 of 8.0 nM (D6 clone) and 11 nM (W2 clone)[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Manzamine A 相关抗体:

    Cell Viability Assay[4]

    Cell Line: SIRC cell
    Concentration: 0.1, 0.5, 1, 2, 3, 5, and 10 µM
    Incubation Time: 72 h
    Result: Inhibited SIRC cell viability with an IC50 of 5.6 µM.
    体内研究
    (In Vivo)

    Manzamine A (50 and 100 mol/kg, p.o. or i.p.) inhibits the growth of the rodent malaria parasite Plasmodium berghei in infected mice[6].
    Manzamine A (8 mg/kg, i.p., daily for 8 consecutive days) prolongs the survival of SW mice to 20 days[7].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Plasmodium berghei in infected mice[6]
    Dosage: 50 or 100 mol/kg
    Administration: Intraperitoneal injection (i.p.) or oral administration (p.o.)
    Result: Inhibited the growth of the rodent malaria parasite Plasmodium berghei.
    Prolonged the survival of highly parasitaemic mice.
    分子量

    548.76

    Formula

    C36H44N4O
    CAS 号
    结构分类
    初始来源

    Okinawan marine sponge
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : 10 mg/mL (18.22 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.8223 mL 9.1115 mL 18.2229 mL
    5 mM 0.3645 mL 1.8223 mL 3.6446 mL
    查看完整储备液配制表

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献

    Manzamine A 相关分类

    完整储备液配制表

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.8223 mL 9.1115 mL 18.2229 mL 45.5573 mL
    5 mM 0.3645 mL 1.8223 mL 3.6446 mL 9.1115 mL
    10 mM 0.1822 mL 0.9111 mL 1.8223 mL 4.5557 mL
    15 mM 0.1215 mL 0.6074 mL 1.2149 mL 3.0372 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Manzamine A104196-68-1Keramamine AGSK-3CDKParasiteProton PumpHSVAutophagyGlycogen synthase kinase-3Glycogen synthase kinase 3Cyclin dependent kinaseHerpes simplex virusManzaminealkaloidAlzheimer'spancreaticcancerantimalarialInhibitorinhibitorinhibit

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