DLX1 - distal-less homeobox 1 Gene

中文名称：无远端同源框 1

种属: Homo sapiens

关于 DLX1

功能概要

该基因编码同源框转录因子基因家族的一个成员，类似于果蝇 distal-less 基因。编码的蛋白质定位于细胞核，在那里它可以作为来自多个 TGF-β 超家族成员的信号的转录调节剂。编码的蛋白质可能在控制颅面模式以及前脑中抑制性神经元的分化和存活中发挥作用。该基因位于 2 号染色体长臂上的另一个家族成员的尾对尾配置中。已经描述了编码不同亚型的可变剪接转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]