Pth - parathyroid hormone Gene

种属: Mus musculus

同用名: Pthp

基因 ID: 19226 | 基因类型: protein coding

关于 Pth

功能概要

Enables hormone activity. Involved in calcium ion homeostasis; magnesium ion homeostasis; and phosphate ion homeostasis. Acts upstream of or within several processes, including homeostasis of number of cells within a tissue; negative regulation of apoptotic process in bone marrow cell; and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in 2nd branchial arch; 3rd branchial pouch; 3rd branchial pouch dorsal endoderm; foregut gland; and parathyroid gland. Human ortholog(s) of this gene implicated in several diseases, including chronic kidney disease; diabetes mellitus (multiple); familial isolated hypoparathyroidism; hyperphosphatemia; and secondary hyperparathyroidism. Orthologous to human PTH (parathyroid hormone). [provided by Alliance of Genome Resources, Apr 2022]

Pth 基因产物(1)

mRNA	Protein	Name
NM_020623.2	NP_065648.1	parathyroid hormone precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables hormone activity	IDA IDA: 通过直接分析推断	11606467	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	19723499	MGI
acts upstream of bone mineralization	IMP IMP: 通过突变表型推断	19968565	MGI
involved in calcium ion homeostasis	IMP IMP: 通过突变表型推断	19968565	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IGI IGI: 通过遗传相互作用推断	21048959	MGI
acts upstream of or within intracellular calcium ion homeostasis	IDA IDA: 通过直接分析推断	12488435	MGI
involved in magnesium ion homeostasis	IMP IMP: 通过突变表型推断	19968565	MGI
acts upstream of or within negative regulation of apoptotic process in bone marrow cell	IGI IGI: 通过遗传相互作用推断	21048959	MGI
involved in phosphate ion homeostasis	IMP IMP: 通过突变表型推断	19968565	MGI
acts upstream of or within positive regulation of cell proliferation in bone marrow	IGI IGI: 通过遗传相互作用推断	21048959	MGI
acts upstream of or within positive regulation of osteoclast proliferation	IGI IGI: 通过遗传相互作用推断	21048959	MGI
acts upstream of or within positive regulation of signal transduction	IMP IMP: 通过突变表型推断	15910753	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15910753	MGI
acts upstream of or within regulation of gene expression	IDA IDA: 通过直接分析推断	15910753	MGI
acts upstream of signal transduction	IMP IMP: 通过突变表型推断	15910753	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15910753	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	11606467	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

parathyroid hormone

相关产品

Approval

生物活性分子 (7)

目录号	产品名	作用方式	纯度	是否罕见病
HY-P0059	Teriparatide	Agonist	99.94%	否
HY-P1955A	Etelcalcetide hydrochloride	Activator	99.45%	否
HY-17613	Evocalcet	Activator	98.39%	否
HY-109106A	Upacicalcet sodium	Agonist	99.91%	否
HY-P1955	Etelcalcetide	Activator	/	否
HY-109106	Upacicalcet	Agonist	/	否
HY-P0059A	Teriparatide acetate hydrate	Agonist	/	否

Clinical Phase

生物活性分子 (1)

目录号	产品名	作用方式	纯度	Phase
HY-100856	PCO371	Agonist	99.67%	Phase 1

Pre-clinical Phase

生物活性分子 (49)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P1852	TIP 39, Tuberoinfundibular Neuropeptide		99.84%	否
HY-112171	γ-L-Glutamyl-L-alanine	Modulator	98.0%	否
HY-P4385	(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat)	Antagonist	99.32%	否
HY-P2426	(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)	Antagonist	99.70%	否
HY-P3075	pTH-Related Protein (1-34) (human,mouse,rat)		99.89%	否
HY-P4823	pTH (1-37) (human)		99.91%	否
HY-P1418A	DPC-AJ1951 TFA	Agonist	99.38%	否
HY-P4697A	pTH (44-68) (human) TFA		98.09%	否
HY-P10078	pTH (39-84) (human)	Activator	98.88%	否
HY-P1252	Parathyroid Hormone (1-34), bovine	Agonist	99.88%	否
HY-P10909	Canvuparatide	Agonist	95.48%	否
HY-P4697	pTH (44-68) (human)		/	否
HY-P4715	(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat)		99.08%	否
HY-10003A	1α-Hydroxy-3-epi-vitamin D3	Inhibitor	99.30%	否
HY-109106B	(Rac)-Upacicalcet		95.0%	否
HY-113918	SW-106	Antagonist	/	否
HY-15106	SB-423557	Antagonist	/	否
HY-32351B	3-epi-Calcifediol		/	否
HY-P10309	[Nle8,18,Tyr34]-pTH (3-34) amide (human)	Ligand	/	否
HY-P10313	[Nle8,18,Tyr34]-pTH (3-34) amide (bovine)	Inhibitor	/	否
HY-P1252A	Parathyroid Hormone (1-34), bovine TFA	Agonist	/	否
HY-P1418	DPC-AJ1951	Agonist	/	否
HY-P4690	pTH (13-34) (human)		/	否
HY-P4692	pTH (1-44) (human)		/	否
HY-P4696	pTH (3-34) (bovine)		/	否
HY-P4700	pTH (53-84) (human)		/	否
HY-P4701	pTH-Related Protein (1-34) amide (human, mouse, rat)		/	否
HY-P4817	Human PTH-(1-31)		/	否
HY-P4818	Human PTH-(1-31) amide		/	否
HY-P4835	pTH (2-34) (human)		/	否
HY-P4849	pTH-Related Protein (1-37) (human, mouse, rat)	Activator	/	否
HY-P4856	pTH-Related Protein (1-40) (human, mouse, rat)	Activator	/	否
HY-P4857	pTH-Related Protein (7-34) amide (human, mouse, rat)		/	否
HY-P4862	Biotinyl-pTH (1-34) (human)	Activator	/	否
HY-RS11394	PTH Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS11395	PTH1R Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS11396	PTH2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS11397	PTH2R Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS11454	PTRH2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-W282259	PTH-tyrosine		/	否
HY-112171R	γ-L-Glutamyl-L-alanine (Standard)	Modulator	/	否
HY-171446	TAK-075	Antagonist	/	否
HY-17613S	Evocalcet-d4	Activator	/	否
HY-RS16633	Pth Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17667	Pth1r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS20090	Pth2r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23068	Pth Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24128	Pth1r Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS26593	Pth2r Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

抗体抑制剂 (1)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P991361	ABX-10241	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Pth	NCBI	NCBI:5741
Macaca fascicularis	Pth	NCBI	NCBI:102145320

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