EEF2 - eukaryotic translation elongation factor 2 Gene

中文名称：真核翻译延伸因子 2

种属: Homo sapiens

同用名: EF2; EF-2; EEF-2; SCA26

基因 ID: 1938 | 基因类型: protein coding

关于 EEF2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,976,056-3,985,463 (from NCBI)

This gene has 7 transcripts (splice variants), 222 orthologues, 18 paralogues and is associated with 3 phenotypes. Ubiquitous expression in ovary (RPKM 918.2), thyroid (RPKM 609.1) and 25 other tissues.

功能概要

该基因编码 GTP 结合翻译延伸因子家族的成员。这种蛋白质是蛋白质合成的必要因素。它促进新生蛋白链从核糖体的 A 位点到 P 位点的 GTP 依赖性易位。该蛋白被 EF-2 激酶磷酸化完全灭活。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]

EEF2 基因产物(1)

mRNA	Protein	Name
NM_001961.4	NP_001952.1	elongation factor 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase activity	IDA IDA: 通过直接分析推断	26593721	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19417104	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	23823123	GOA
enables ribosome binding	IDA IDA: 通过直接分析推断	23636399	GOA
enables translation elongation factor activity	IDA IDA: 通过直接分析推断	26593721	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of translation	IMP IMP: 通过突变表型推断	23184662	GOA
involved in translational elongation	IDA IDA: 通过直接分析推断	26593721	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	25064856	GOA
part of ribonucleoprotein complex	IDA IDA: 通过直接分析推断	18809582	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EEF2 蛋白结构

GTP_EFTU

GTP_EFTU_D2

EFG_II

EFG_IV

EFG_C

0
200
400
600
800
858 a.a.

蛋白主名

其他名称

elongation factor 2

epididymis secretory sperm binding protein

EEF2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	EEF2	P13639	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	EEF2	P13639	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	EEF2	P13639	HTT	Homo sapiens	P42858	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

EEF2 抗体

目录号	产品名	应用	反应物种
HY-P81272	Elongation factor 2 Antibody (YA962)	WB, ICC/IF, ChIP	Human
HY-P81272A	Elongation factor 2 Antibody (YA963)	WB, ICC/IF	Human, Mouse, Monkey, Rat
HY-P81272B	Elongation factor 2 Antibody (YA964)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P82836	Phospho-Elongation Factor 2 (Thr56/Thr58) Antibody (YA2581)	WB	Human
HY-P84086	Elongation factor 2 Antibody (YA3783)	WB, IHC-P, ICC/IF, ELISA	Human
HY-P85428	Elongation factor 2 Antibody (YA5120)	WB	Human, Mouse, Rat
HY-P85535	Elongation factor 2 Antibody (YA5227)	WB, IHC-P, ICC/IF, ELISA	Human

关联疾病

疾病名称

别名

Spinocerebellar Ataxia 26

Spinocerebellar Ataxia Type 26	SCA26
Ataxia, Spinocerebellar, Type 26

Diphtheria

Corynebacterium Infections	Corynebacterium Infection
Diphtherial Infection	Infection Due To Corynebacterium Diphtheriae

Refractory Hairy Cell Leukemia

Refractory Hematologic Cancer

Refractory Hematologic Malignancy

Fusariosis

Fusarium Infection

Retinal Melanoma

Malignant Retinal Melanoma

Malignant Melanoma Of Retina

Cerebellar Ataxia Type 41

Sca41

Myopathy, Tubular Aggregate, 1

Tubular Aggregate Myopathy	Tam
Myopathy With Tubular Aggregates	TAM1
Myopathy, Tubular Aggregate	Tubular Aggregate Myopathy 1

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-117684	Cabamiquine	Inhibitor	99.93%	Phase 2
HY-117684A	Cabamiquine succinate	Inhibitor	99.80%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12320	Cycloheximide	Inhibitor	99.82%	否
HY-110096	A-484954	Inhibitor	99.34%	否
HY-100576	NH125	Inhibitor	99.63%	否
HY-126396	Sordarin sodium	Inhibitor	99.0%	否
HY-146324	PROTAC eEF2K degrader-1	Activator	98.64%	否
HY-120904	AMPK-IN-1	Activator	95.19%	否
HY-112393	TX-1918	Inhibitor	/	否
HY-121828	TX-1123	Inhibitor	/	否
HY-123024	Cefatrizine		/	否
HY-176149	Fluoxetine-Conjugated Platinum(IV) prodrug-1		/	否
HY-177720	eEF2K degrader-2		/	否
HY-RS04180	EEF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS04181	EEF2K Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS20013	Eef2k Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS20725	Eef2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS26516	Eef2k Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27237	Eef2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	EEF2	RGD	RGD:61979
Canis familiaris	EEF2	VGNC	VGNC:40209
Mus musculus	EEF2	MGD	MGI:95288
Bos taurus	EEF2	VGNC	VGNC:28335
Felis catus	EEF2	VGNC	VGNC:78444
Macaca mulatta	EEF2	VGNC	VGNC:97763
Others	EEF2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

EEF2 - eukaryotic translation elongation factor 2 Gene

关于 EEF2

功能概要

EEF2 基因产物(1)

EEF2 蛋白结构

EEF2 蛋白互作信息

EEF2 抗体

关联疾病

直系同源

热门区域

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EEF2 - eukaryotic translation elongation factor 2 Gene

关于 EEF2

功能概要

EEF2 基因产物(1)

EEF2 蛋白结构

EEF2 蛋白互作信息

EEF2 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z