2. Protein Tyrosine Kinase/RTK Neuronal Signaling Stem Cell/Wnt TGF-beta/Smad JAK/STAT Signaling Epigenetics Immunology/Inflammation
  3. Src CaMK PKA EGFR PKC COX
  4. TX-1123

TX-1123 是一种有效的蛋白酪氨酸激酶 (PTK) 抑制剂，针对于 Src、eEF2-K、PKA 和 EGFR-K/PKC。TX-1123 是一种环氧合酶 (COX) 抑制剂，对 COX2 和 COX1 的 IC50 值分别为 1.16 μM 和 15.7 μM。TX-1123 具有低线粒体毒性。TX-1123 可用于癌症研究。

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TX-1123 Chemical Structure

TX-1123 Chemical Structure

CAS No. : 157397-06-3

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TX-1123 相关抗体

Top Publications Citing Use of Products

查看 Src 亚型特异性产品:

查看所有亚型
Lck

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 PKC 亚型特异性产品:

查看所有亚型
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer[1][2].

IC50 & Target[2]

COX-2

1.16 nM (IC50)

COX-1

15.7 μM (IC50)

体外研究
(In Vitro)

TX-1123 (NIH3T3 细胞) 抑制 Src-K、eEF2-K、PKA、PKC、EGFR-k，IC50 值分别为 2.2、3.2、9.6、320 和 320 μM[1]。
TX-1123 (线粒体悬浮液) 具有较弱的线粒体毒性和 ATP 合成抑制活性，IC50 值为 5 μM[1]。
TX-1123 (0-1000 μM; 48 h) 具有抗肿瘤活性，对 HepG2、HCT116 和大鼠肝细胞的 IC50 值分别为 3.66、39 和 57 μM[1] 。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TX-1123 相关抗体:

Cell Viability Assay[1]

Cell Line: HepG2, HCT116, and Rat hepatocytes
Concentration: 0-1000 μM
Incubation Time: 48 hours
Result: Inhibited tumor cell growth in a dose-dependent manner.
分子量

312.40

Formula

C20H24O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TX-1123 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TX-1123157397-06-3TX1123TX 1123SrcCaMKPKAEGFRPKCCOXCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesProtein kinase AEpidermal growth factor receptorErbB-1HER1Protein kinase CCyclooxygenaseprotein tyrosine kinasecancerNIH3T3 cellsmitochondrialtoxicityInhibitorinhibitorinhibit

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目录号：
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