2. Gene
  3. Smad2 - SMAD family member 2 Gene

Smad2 - SMAD family member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Madh2

基因 ID: 29357 | 基因类型: protein coding

关于 Smad2

功能概要

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; SMAD binding activity; and enzyme binding activity. Predicted to contribute to DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including adrenal gland development; regulation of gene expression; and transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nucleus. Part of protein-containing complex. Used to study hepatocellular carcinoma. Biomarker of colon Cancer and myocardial infarction. Human ortholog(s) of this gene implicated in Lynch syndrome; cervical cancer; and ovarian Cancer. Orthologous to human SMAD2 (Smad Family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Smad2 基因产物(4)

mRNA Protein Name
NM_001277450.1 NP_001264379.1 mothers against decapentaplegic homolog 2
NM_019191.2 NP_062064.1 mothers against decapentaplegic homolog 2
NM_001277450.1 NP_001264379.1 mothers against decapentaplegic homolog 2
NM_019191.2 NP_062064.1 mothers against decapentaplegic homolog 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16362038 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in SMAD protein signal transduction IMP
IMP: 通过突变表型推断
22073128 RGD
involved in adrenal gland development IDA
IDA: 通过直接分析推断
12844345 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
32065356 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
33409963 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15987742 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22073128 RGD
involved in signal transduction involved in regulation of gene expression IMP
IMP: 通过突变表型推断
22073128 RGD
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
22073128 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IDA
IDA: 通过直接分析推断
16959941 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

mothers against decapentaplegic homolog 2

SMAD 2

mad-related protein 2

mothers against DPP homolog 2

相关产品

Approval
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99720 Luspatercept Inhibitor 98.92% 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-N2037A Higenamine hydrochloride 99.52% Phase 1
HY-N2037 Higenamine 98.91% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99351 Andecaliximab Inhibitor ≥99.0% Phase 3
Pre-clinical Phase
生物活性分子 (35)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-116084 Trimethylamine N-oxide Activator ≥98.0% 否
HY-100830 NCB-0846 Inhibitor 99.61% 否
HY-108915 Trimethylamine N-oxide dihydrate Activator ≥98.0% 否
HY-116084S Trimethylamine N-oxide-d9 Activator 99.76% 否
HY-N6985 Baccatin III 99.19% 否
HY-100444 SIS3 free base Inhibitor 98.02% 否
HY-18766 EW-7195 Inhibitor 98.84% 否
HY-144043 ALK5-IN-8 Inhibitor 98.06% 否
HY-100448A Butaprost 99.2% 否
HY-118528A TP0427736 hydrochloride Inhibitor 99.22% 否
HY-123900 AZ12799734 Inhibitor 98.07% 否
HY-122856 AZ12601011 Inhibitor 99.78% 否
HY-P10414A Klotho-derived peptide 1 hydrochloride Inhibitor 98.57% 否
HY-100830A NCB-0970 Control / 否
HY-N4107 Phyllanthin Inhibitor 99.96% 否
HY-116084S1 Trimethylamine-N-oxide-13C3 Activator / 否
HY-117511 HJC0123 / 否
HY-120973 Butaprost free acid / 否
HY-149136 MORF-627 Inhibitor / 否
HY-161398 TGFβRII-IN-3 / 否
HY-162404 (14S,15R)-14-Deoxyoxacyclododecindione Inhibitor / 否
HY-162405 Smad2/3-IN-1 Inhibitor / 否
HY-168607 ALK5-IN-83 Inhibitor / 否
HY-170578 SIRT2-IN-17 Inhibitor / 否
HY-172108 TGFβRI-IN-7 Inhibitor / 否
HY-P10359 TAT-QFNP12 Inhibitor / 否
HY-P10363 Tiger17 Activator / 否
HY-P10414 Klotho-derived peptide 1 Inhibitor / 否
HY-RS13393 SMAD2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W722562 Trimethylamine oxide-15N / 否
HY-118528 TP0427736 Inhibitor / 否
HY-N2037AS1 Higenamine-d4-1 hydrochloride / 否
HY-RS17208 Smad2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23660 Smad2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W108953 Myristoyl tetrapeptide-12 Activator / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991316 KD014 / 否
HY-P99720A Luspatercept (mIgG2a) Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Smad2 NCBI NCBI:4087
Mus musculus Smad2 NCBI NCBI:17126
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