2. Gene
  3. Rest - RE1-silencing transcription factor Gene

Rest - RE1-silencing transcription factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Nrsf

基因 ID: 83618 | 基因类型: protein coding

关于 Rest

功能概要

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of cellular biosynthetic process; negative regulation of dense core granule biogenesis; and response to ischemia. Located in chromatin and nucleus. Part of transcription repressor complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Rest 基因产物(1)

mRNA Protein Name
NM_031788.2 NP_113976.2 RE1-silencing transcription factor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
9454838 RGD
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
19342457 RGD
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
17130167 RGD
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
17130167 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
21284946 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
10491605 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10490617 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IMP
IMP: 通过突变表型推断
22371606 RGD
involved in modification of synaptic structure IMP
IMP: 通过突变表型推断
22960932 RGD
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
17130167 RGD
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
11516394 RGD
involved in negative regulation of aldosterone biosynthetic process IMP
IMP: 通过突变表型推断
19342457 RGD
involved in negative regulation of calcium ion-dependent exocytosis IMP
IMP: 通过突变表型推断
21536750 RGD
involved in negative regulation of cortisol biosynthetic process IMP
IMP: 通过突变表型推断
19342457 RGD
involved in negative regulation of dense core granule biogenesis IMP
IMP: 通过突变表型推断
21536750 RGD
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
25108103 RGD
involved in negative regulation of neuron differentiation IMP
IMP: 通过突变表型推断
12657670 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22960932 RGD
involved in neuron differentiation IEP
IEP: 通过表达模式推断
24841827 RGD
involved in positive regulation of programmed cell death IMP
IMP: 通过突变表型推断
12657670 RGD
involved in response to ischemia IDA
IDA: 通过直接分析推断
22371606 RGD
involved in response to ischemia IEP
IEP: 通过表达模式推断
12657670 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
11516394 RGD
located in nucleus IDA
IDA: 通过直接分析推断
7697725 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
10491605 RGD
part of transcription repressor complex IDA
IDA: 通过直接分析推断
17130167 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

RE1-silencing transcription factor

neural-restrictive silencer factor

zinc finger transcription factor REST protein

相关产品

Approval
生物活性分子 (11)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0069 Fludarabine 99.77% 是
HY-A0083 Methacholine chloride Agonist ≥98.0% 是
HY-70057 Safinamide Inhibitor 99.86% 是
HY-70057A Safinamide mesylate Inhibitor 99.07% 是
HY-B1194 Tetramisole hydrochloride 99.93% 否
HY-B0516 Articaine hydrochloride Inhibitor 99.38% 否
HY-A0083B Methacholine bromide Agonist / 否
HY-B0516A Articaine Inhibitor / 否
HY-B0516R Articaine hydrochloride (Standard) Inhibitor / 否
HY-B1194A Tetramisole / 否
HY-B0069R Fludarabine (Standard) / 否
Pre-clinical Phase
生物活性分子 (31)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136833 X5050 Inhibitor 98.05% 否
HY-12680 PRN694 Inhibitor ≥99.0% 否
HY-136460 Calcium ionophore I 99.6% 否
HY-W013712 GI-530159 Activator 99.72% 否
HY-103178 MRE3008F20 Antagonist 99.70% 否
HY-142683 SCP1-IN-2 Inhibitor 98.77% 否
HY-RS11853 REST Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-106667 DL 071IT Inhibitor 98.81% 否
HY-142682 SCP1-IN-1 Inhibitor 98.42% 否
HY-149483 CVN417 Antagonist / 否
HY-70057S1 Safinamide-d4-1 Inhibitor 98.90% 否
HY-P10817A Corza6 TFA Inhibitor 95.53% 否
HY-152901 Chol-N3 / 否
HY-103298 MNI-caged kainate / 否
HY-116790B (±)-Penbutolol Antagonist / 否
HY-125452 DiSBAC10 / 否
HY-137618B Rp-dGTPαS / 否
HY-159986 X-17 Inhibitor / 否
HY-161272 Nav1.8-IN-6 Inhibitor / 否
HY-162478 GR-28 / 否
HY-A0083C Methacholine iodide Agonist / 否
HY-P10817 Corza6 Inhibitor / 否
HY-P5152 Scorpion toxin Tf2 Activator / 否
HY-W328882 3-(2-Aminopropyl)phenol / 否
HY-174754 Human CCL28 mRNA / 否
HY-174758 Human CCL24 mRNA / 否
HY-174759 Human CCL23 mRNA / 否
HY-174760 Human CCL22 mRNA / 否
HY-70057S4 Safinamide-d5 Inhibitor / 否
HY-RS17141 Rest Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23588 Rest Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rest NCBI NCBI:5978
Macaca fascicularis Rest NCBI NCBI:102116020
Mus musculus Rest NCBI NCBI:19712
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