2. Apoptosis
  3. MDM-2/p53
  4. GN25

GN25 是一种特异性的 p53-Snail binding 抑制剂，具有抗肿瘤作用。

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GN25 Chemical Structure

GN25 Chemical Structure

CAS No. : 1227401-27-5

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规格 价格 是否有货 数量
5 mg ￥460
In-stock
10 mg ￥750
In-stock
25 mg ￥1550
In-stock
50 mg ￥2500
In-stock
100 mg ￥4200
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

GN25 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GN25 is a specific p53-Snail binding inhibitor with antitumor effects[1].

体外研究
(In Vitro)

GN25 (10 and 20 μM; 24 h) inhibits cell viability of K-Ras-mutated MEF cells[1].
GN25 (5 μM; 4 h) activates p53 in a K-Ras-dependent manner[1].
GN25 (1-10 μM; 1-6 h) induces p53 and p21 in a dose- and time- dependent manner in K-Ras-mutated A549 and HCT116 cell lines[1].
GN25 activates wild-type p53 in p53WT/MT cells[1].
GN25 (0.25 μM) recovers the masking effect of p53 on CK1/GSK3b-mediated Snail phosphorylation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GN25 相关抗体:

Cell Viability Assay[1]

Cell Line: HCT116, A459 and MKN45 cell lines
Concentration: 10 μM
Incubation Time: 24 h
Result: Obviously suppressed the cell viability of HCT116 and A459 cell lines.

Cell Proliferation Assay[1]

Cell Line: K-Ras-transformed and N-Ras/Myc-transformed MEF cells
Concentration: 10 μM and 20 μM
Incubation Time: 24 h
Result: Inhibited the viability of K-Ras-transformed but not N-Ras/Myc-transformed MEF cells.

Western Blot Analysis[1]

Cell Line: K-Ras-MEF, N-Ras/Myc-MEF and Nontransformed MEF cells
Concentration: 5 μM
Incubation Time: 4 h
Result: Only induced p53 and p21 in K-Ras-MEF cells.

Western Blot Analysis[1]

Cell Line: K-Ras-mutated A549, HCT116 cell lines and MKN45
Concentration: 1, 5, and 10 μM
Incubation Time: 1, 3, and 6 h
Result: Induced p53 and p21 in a dose- and time- dependent manner in A549 and HCT116 cells.
体内研究
(In Vivo)

GN25 (10 and 20 mg/kg; i.p. once a week for 10 weeks) blocks the tumor progression and induces tumor regression in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic mice with A549 xenografts[1]
Dosage: 10 and 20 mg/kg
Administration: Intraperitoneal injection; once a week for 10 weeks
Result: Obviously regressed tumors in mice. Showed no significant toxicity in liver, pancreas and kidney.
分子量

322.33

Formula

C15H14O6S
CAS 号
性状

固体

颜色

Light yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (310.24 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1024 mL 15.5121 mL 31.0241 mL
5 mM 0.6205 mL 3.1024 mL 6.2048 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

GN25 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1024 mL 15.5121 mL 31.0241 mL 77.5603 mL
5 mM 0.6205 mL 3.1024 mL 6.2048 mL 15.5121 mL
10 mM 0.3102 mL 1.5512 mL 3.1024 mL 7.7560 mL
15 mM 0.2068 mL 1.0341 mL 2.0683 mL 5.1707 mL
20 mM 0.1551 mL 0.7756 mL 1.5512 mL 3.8780 mL
25 mM 0.1241 mL 0.6205 mL 1.2410 mL 3.1024 mL
30 mM 0.1034 mL 0.5171 mL 1.0341 mL 2.5853 mL
40 mM 0.0776 mL 0.3878 mL 0.7756 mL 1.9390 mL
50 mM 0.0620 mL 0.3102 mL 0.6205 mL 1.5512 mL
60 mM 0.0517 mL 0.2585 mL 0.5171 mL 1.2927 mL
80 mM 0.0388 mL 0.1939 mL 0.3878 mL 0.9695 mL
100 mM 0.0310 mL 0.1551 mL 0.3102 mL 0.7756 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GN251227401-27-5GN 25GN-25MDM-2/p53antitumorp53HCT116A459MKN45phosphorylationathymic miceInhibitorinhibitorinhibit

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目录号：
HY-117280
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