2. Anti-infection
  3. HCV
  4. GS-6620

GS-6620 是一种强效且具有选择性的丙型肝炎病毒 (HCV) 抑制剂。GS-6620 能抑制 1-6 型基因型亚基因组复制子和 2a 型基因型感染性病毒中的 HCV 复制，其 EC50 值为 0.048-0.68 μM。GS-6620 可用于感染和炎症相关研究，如丙型肝炎病毒 (HCV) 。

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GS-6620

GS-6620 Chemical Structure

CAS No. : 1350735-70-4

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规格 价格 是否有货 数量
1 mg ￥7650
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Customer Review

GS-6620 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GS-6620 is potent and selective HCV inhibitor. GS-6620 inhibits HCV replication in genotype 1-6 subgenomic replicons and genotype 2a infectious virus, with EC50 values of 0.048-0.68 μM. GS-6620 can be used for the researches of infection and inflammation, such as Hepatitis C Virus (HCV)[1][2].

IC50 & Target[1]

GT3a

0.048 μM (EC50)

GT4a

0.11 μM (EC50)

GT6a

0.11 μM (EC50)

GT5a

0.14 μM (EC50)

GT1a

0.18 μM (EC50)

GT1b

0.46 μM (EC50)

GT2a

0.68 μM (EC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEp-2 CC50
95 μM
Compound: 13b
Cytotoxicity against human Hep2 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
Cytotoxicity against human Hep2 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
[PMID: 28124907]
HeLa EC50
> 20 μM
Compound: 13b
Antiviral activity against Ebolavirus Kikwit infected in human HeLa cells assessed as reduction in viral glycoprotein levels preincubated with cells for 2 hrs followed by viral infection measured after 48 hrs by immunostaining based assay
Antiviral activity against Ebolavirus Kikwit infected in human HeLa cells assessed as reduction in viral glycoprotein levels preincubated with cells for 2 hrs followed by viral infection measured after 48 hrs by immunostaining based assay
[PMID: 28124907]
Huh-7 CC50
51 μM
Compound: 13b
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 3 days by calcein-AM dye based fluorescence assay
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 3 days by calcein-AM dye based fluorescence assay
[PMID: 28124907]
MT4 CC50
7.8 μM
Compound: 13b
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
[PMID: 28124907]
体外研究
(In Vitro)

GS-6620 (72 h) 可抑制基因型 1-6 亚基因组复制子和基因型 2a 感染性病毒中的 HCV 复制，其 EC50 值为 0.048-0.68 μM，且对牛病毒性腹泻病毒 (BVDV) 的活性较弱 (EC50 值为 1.5 μM)[1]。
GS-6620 (active metabolite) (0.39-1.3 μM, 70-90 mins) 可抑制 HCV NS5B 聚合酶[1]。
GS-6620 (0-100 μM, 5 days) 在 Huh-7、HepG2、PC-3 和 PBMCs 中显示出低细胞毒性，其 CC50 值分别为 67、66、40 和 >100 μM[1]。
GS-6620 (20-100 μM, 5-10 days) 不会降低 HepG2 细胞中的线粒体 DNA 含量，也不会抑制 PC-3 细胞中的线粒体蛋白质合成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GS-6620 相关抗体:
体内研究
(In Vivo)

GS-6620 (给大鼠 1000 mg/kg 或给犬 60 mg/kg，灌胃，每日一次，持续 26-39 周) 对 SD 大鼠和比格犬无不良反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

644.61

Formula

C29H37N6O9P
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

GS-6620 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GS-66201350735-70-4GS6620GS 6620HCVHepatitis C virusVirusHCV NS5BHuh-7HepG2PC-3PBMCsInhibitorinhibitorinhibit

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目录号：
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