2. Metabolic Enzyme/Protease
  3. FXR
  4. GSK8062

GSK8062是一种法尼醇X受体（FXR）激动剂，具有改善化合物开发性参数的活性。GSK8062的类似物1c在体重增加和血清葡萄糖水平方面表现出降低效果。

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GSK8062

GSK8062 Chemical Structure

CAS No. : 943549-47-1

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GSK8062 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK8062 is a farnesoid X receptor (FXR) agonist with activity that improves compound development parameters. Analog 1c of GSK8062 showed a reduction in weight gain and serum glucose levels[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CV-1 EC50
68 nM
Compound: 1b, GSK-8062
Agonist activity at FXR expressed in african green monkey CV1 cells by luciferase reporter transient transfection assay
Agonist activity at FXR expressed in african green monkey CV1 cells by luciferase reporter transient transfection assay
[PMID: 18621523]
CV-1 EC50
68 nM
Compound: 1b, GSK-8062
Agonist activity at human FXR LBD iexpressed in monkey CV-1 cells assessed as transactivation of luciferase reporter gene expression
Agonist activity at human FXR LBD iexpressed in monkey CV-1 cells assessed as transactivation of luciferase reporter gene expression
[PMID: 21256005]
CV-1 EC50
68 nM
Compound: 1b, GSK8062
Agonist activity at human FXR LBD transfected in african green monkey CV1 cells after overnight incubation by luciferase reporter gene assay
Agonist activity at human FXR LBD transfected in african green monkey CV1 cells after overnight incubation by luciferase reporter gene assay
[PMID: 21890356]
分子量

532.41

Formula

C30H23Cl2NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK8062 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK8062943549-47-1GSK 8062GSK-8062FXRNR1H4Inhibitorinhibitorinhibit

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目录号：
HY-111049
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