2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. H-Leu-Ser-Lys-Leu-OH

H-Leu-Ser-Lys-Leu-OH 是一种位于 LAP 氨基端的延迟相关肽，对 TGF-β1 激活有抑制作用。H-Leu-Ser-Lys-Leu-OH 被 KRFK (HY-P3970) 结合后能够阻断 TGF-β1 的信号转导，由此阻止肝损伤和纤维化的进展。

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Custom Peptide Synthesis

H-Leu-Ser-Lys-Leu-OH Chemical Structure

H-Leu-Ser-Lys-Leu-OH Chemical Structure

CAS No. : 162559-45-7

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H-Leu-Ser-Lys-Leu-OH 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

H-Leu-Ser-Lys-Leu-OH (LSYL) is a latency-associated peptide at the amino terminus of LAP, with inhibitory effect on TGF-β1 activation. H-Leu-Ser-Lys-Leu-OH, binding with KRFK (HY-P3970), can block the signal transduction of TGF-β1, and prevent the progression of hepatic damage and fibrosis[1].

IC50 & Target

TGF-β1[1]
体外研究
(In Vitro)

H-Leu-Ser-Lys-Leu-OH (LSKL) 也可以阻断 TSP-1 对 TGF-β1 的激活，并降低 KRFK 肽对 TGF-β1 的激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

H-Leu-Ser-Lys-Leu-OH 相关抗体:
体内研究
(In Vivo)

H-Leu-Ser-Lys-Leu-OH (LSKL) (100 μg/0.5 mL; 腹腔注射; 每日给药，共 4 周; 并伴随着 DMN 的处理) 能够保护二甲基亚硝胺 (DMN) 处理 (10 mg/kg; 腹腔注射; 每周连续3天给药, 共 4 周) 导致的大鼠肝萎缩。H-Leu-Ser-Lys-Leu-OH 还可以预防肝损伤和纤维化的进展[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

459.58

Formula

C21H41N5O6
CAS 号
Sequence Shortening

LSKL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

H-Leu-Ser-Lys-Leu-OH 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H-Leu-Ser-Lys-Leu-OH162559-45-7TGF-beta/SmadTransforming growth factor betaInhibitorinhibitorinhibit

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