2. Peptides
  3. Helospectin I

Helospectin I 是血管活性肠肽 (VIP) 家族的神经肽。Helospectin I 具有血管扩张和抗高血压活性，并可降低血压。Helospectin I 最初是从蜥蜴 Heloderma suspectum 的唾液腺毒液中分离出来的。

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Helospectin I Chemical Structure

Helospectin I Chemical Structure

CAS No. : 93438-37-0

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Helospectin I 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Helospectin I is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin I has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin I is originally isolated from the salivary gland venom of the lizard Heloderma suspectum[1][2].

IC50 & Target

Vasoactive intestinal peptide (VIP)[1]
体外研究
(In Vitro)

Helospectin I (suffusion at 0.1 nM, in bicarbonate buffer for 30 min) evokes significant, sustained and similar vasodilation in the intact hamster cheek pouch[1].
Helospectin I relaxes the Phenylephrine-contracted rat femoral arteries with pEC50 of 6.82[2].
Helospectin I (0.1 nM-1 μM) inhibits the binding of 125I-labeled VIP and 125I-secretin to dispersed chief cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Helospectin I 相关抗体:
体内研究
(In Vivo)

Helospectin I (0.03-2 nmol/kg, 100 μL of infusion at the left jugular vein) reduces blood pressure in rats[2].
Helospectin I (0.1-0.8 nmol /kg, i.v.) increases plasma levels of glucagon in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats[2]
Dosage: 0.03, 0.3, 1, 2 nM/kg
Administration: 100 μL of infusion at the left jugular vein, followed by washing the catheter with 100 μL saline.
Result: Reduced the blood pressure, but was less effective than vasoactive intestinal peptide (VIP) in the low dose range.
Animal Model: Mice[3]
Dosage: 0.1, 0.2, 0.4, 0.8 nM /kg
Administration: Intravenous injection (i.v.)
Result: Markedly stimulated glucagon secretion, and had no direct action on insulin secretion.
分子量

4095.63

Formula

C183H293N47O59
CAS 号
Sequence Shortening

HSDATFTAEYSKLLAKLALQKYLESILGSSTSPRPPSS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Helospectin I93438-37-0OthersVasodilatoryantihypertensiveblood pressureneuropeptidehamsterfemoral arterieschief cellInhibitorinhibitorinhibit

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Helospectin I
目录号：
HY-P3053
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