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  2. HPV16 E7 (86-93)

HPV16 E7 (86-93) 

目录号: HY-P1778
产品使用指南

HPV16 E7 (86-93) 是人类白细胞抗原 (HLA)-A2.1 限制的 HPV16 E7 衍生肽。HPV16 E7 (86-93) 在宫颈癌中具有免疫原性。

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HPV16 E7 (86-93) Chemical Structure

HPV16 E7 (86-93) Chemical Structure

CAS No. : 160212-93-1

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Description

HPV16 E7 (86-93) is a human leukocyte antigen (HLA)-A2.1 restricted HPV16 E7-derived peptide. HPV16 E7 (86-93) is immunogenic in cervical carcinomas[1][2].

In Vitro

HPV16 E7 (86-93) specific T cells are expandable upon IVS (in vitro stimulation) with cognate peptide-pulsed dendritic cells (DCs) and are reactive against peptide-pulsed targets or, in case of the E711-20 epitope-specific T cells, against HPV16 E7 expressing CaSki cell line[1].
For peptide HPV16 E7 (86-93), the only response against K562 cells pulsed with the corresponding peptide was significantly blocked by anti-HLA class I Ab w6/32, which was not the case for HPV16 E7 expressing tumor cell line CaSki. Precursor T cells specific for HPV16 E7 (86-93) peptide is able to differentiate, at least in vitro, into HPVspecific effector cells[1].
HPV16 E7 peptide-loaded autologous dendritic cells (DCs) are able to stimulate a specific cytotoxic CD8+ T-cell response[2].

In Vivo

HPV16 E7 (86-93) peptide in IVS culture has specific T cell expansion. The HPV16 E7 (86-93) specific T cells produced does not recognize naturally HPV16 E7 expressing cell line CaSki. HPV16 E7 (86-93) peptides also has similar observations in transgenic mice. The HPV16 E7 (86-93) peptide is able to induce cytotoxic T lymphocyte (CTL) responses if loaded on the antigen presenting HLA class I molecules, but that the peptide appears not to be processed or presented by HPV16 infected cells[1].

Molecular Weight

815.03

Formula

C₃₇H₆₆N₈O₁₀S

CAS No.

160212-93-1

Sequence

{Thr}{Leu}{Gly}{Ile}{Val}{Cys}{Pro}{Ile}

Sequence Shortening

TLGIVCPI

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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× = ×
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Keywords:

HPV16 E7 (86-93)OthersImmunogeniccervicalcarcinomasHLA-A2cytotoxicCD8+T-cellInhibitorinhibitorinhibit

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产品名称:
HPV16 E7 (86-93)
目录号:
HY-P1778
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