2. Apoptosis
  3. Caspase
  4. IDN-1965

IDN-1965 是一种不可逆的、广谱的多胱天蛋白酶 (Caspase) 抑制剂。IDN-1965 通过抑制 caspase 活性，阻止了下游凋亡执行事件 (如 DNA 酶激活) 的发生，且显著延迟了细胞色素 c 的释放。IDN-1965 在心肌细胞凋亡的小鼠中显著延迟了小鼠的死亡时间。IDN-1965 完全预防了扩张性心肌病小鼠的左心室扩张、收缩功能障碍和纤维化。IDN-1965 可用于研究心衰等凋亡相关疾病和凋亡启动机制。

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IDN-1965

IDN-1965 Chemical Structure

CAS No. : 204919-14-2

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IDN-1965 相关抗体

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查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDN-1965 is an irreversible, broad-spectrum caspase inhibitor. IDN-1965 prevents downstream apoptotic events (such as DNase activation) and significantly delays cytochrome c release by inhibiting caspase activity. IDN-1965 significantly delayed death in mice with cardiomyocyte apoptosis. IDN-1965 completely prevents left ventricular dilation, systolic dysfunction, and fibrosis in mice with dilated cardiomyopathy. IDN-1965 can be used to study apoptosis-related diseases such as heart failure and the mechanisms of apoptosis initiation[1][2].

分子量

419.45

Formula

C21H26FN3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IDN-1965 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDN-1965204919-14-2IDN1965IDN 1965CaspaseApoptosisHeart FailureCardiomyopathyBcl-2Transgenic MiceMyocyte DeathCaspase InhibitorDilated CardiomyopathyInhibitorinhibitorinhibit

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IDN-1965
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