1. NF-κB Cell Cycle/DNA Damage Anti-infection Apoptosis
  2. NF-κB DNA/RNA Synthesis Parasite Apoptosis
  3. Isochamaejasmin

Isochamaejasmin  (Synonyms: 异狼毒素)

目录号: HY-N3497
产品使用指南

Isochamaejasmin 是一种双黄酮类化合物,具有抗癌、抗疟原虫和杀虫活性。Isochamaejasmin 显示出有效的 NF-κB (NF-κB) 激活活性。Isochamaejasmin 可通过线粒体途径引起 AW1 细胞 DNA 损伤并诱导细胞凋亡 (apoptosis)。Isochamaejasmin 还具有中等抗疟原虫活性 (对恶性疟原虫的 IC50 为 7.3 μM) 和相对较低的细胞毒性 (CC50 为 29.0 μM)。

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Isochamaejasmin Chemical Structure

Isochamaejasmin Chemical Structure

CAS No. : 93859-63-3

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent NF-κB (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells[1][2]. Isochamaejasmin also has a moderate antiplasmodial activity (IC50 of 7.3 μM for P. falciparum) and relatively low cytotoxicity (CC50 of 29.0 μM)[3].

体外研究
(In Vitro)

Isochamaejasmin (6.25-100μM; 24-72 h) 通过时间和剂量依赖性方式显示出对 AW1 细胞的潜在毒性。Isochamaejasmin (1000 mg/L, 500 mg/L, 250 mg/L, 125 mg/L, 62.5 mg/L; 24 h, 48 h, 72 h, and 96 h) 对 H. zea 幼虫具有随时间的潜在毒性和剂量依赖性行为[1]
Isochamaejasmin (40-80μM; 24 h) 导致 DNA 损伤并增加 AW1 细胞中 γH2AX 和 OGG1 的水平。使细胞周期停滞在G2/M期[1]
Isochamaejasmin (20-80μM; 24 h) 剂量依赖性诱导 AW1 细胞凋亡[1]
Isochamaejasmin (20-80μM; 24 h) 显示 MMP 下降,Bax/Bcl-2 表达上调,导致细胞色素 c 释放到胞质溶胶中,caspase-3/9 激活,PARP 裂解 [1]
Isochamaejasmin 显示 AW1 细胞中活性氧 (ROS) 水平的剂量依赖性升高、脂质过氧化产物的积累和抗氧化酶的失活[1]
Isochamaejasmin 在转染的 HeLa 细胞中诱导 NF-κB 定向报告基因的表达,EC50 为 3.23 μM。Isochamaejasmin 刺激的 NF-κB 报告基因活性伴随着 NF-κB 蛋白的核转位,并被 IκBα 的显性失活结构阻断。Isochamaejasmin 还诱导丝裂原活化蛋白激酶 ERK1/2 和 p38 以及 PKCδ的时间依赖性磷酸化[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Larvae and neuronal cells (AW1)
Concentration: 6.25 μM, 12.5 μM, 25 μM, 50 μM and 100 μM
Incubation Time: 24 h, 48 h and 72 h
Result: Had potential toxicity against H. zea both in vivo and in vitro via time- and dose-dependent manners.

Cell Cycle Analysis[1]

Cell Line: Neuronal cells (AW1)
Concentration: 40 μM and 80 μM
Incubation Time: 24 h
Result: The cell cycle was arrested at the G2/M phase.

Apoptosis Analysis[1]

Cell Line: Neuronal cells (AW1)
Concentration: 20 μM, 40 μM, and 80 μM
Incubation Time: 24 h
Result: Induced apoptosis via the mitochondrial pathway in AW1 cells.

Western Blot Analysis[1]

Cell Line: Neuronal cells (AW1)
Concentration: 20 μM, 40 μM, and 80 μM
Incubation Time: 24 h
Result: Showed upregulation of Bax/Bcl-2 expression resulting in the release of cytochrome c into the cytosol, activation of caspase-3/9, and cleavage of PARP.
分子量

542.49

Formula

C30H22O10

CAS 号
中文名称

异狼毒素

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HY-N3497
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