1. PI3K/Akt/mTOR
    Anti-infection
  2. PI4K
    Parasite
  3. KDU731

KDU731 

目录号: HY-103583 纯度: 98.0%
产品使用指南

KDU731,具有口服活性的 C. parvum PI4K 抑制剂,阻断体内外隐孢子虫感染,IC50 值为 25 nM。KDU731 是研究隐孢子虫引起的腹泻的有望候选药物,具有广泛的安全性。

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KDU731 Chemical Structure

KDU731 Chemical Structure

CAS No. : 1610610-48-4

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     可免费申领三个不同产品的试用装。

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规格 价格 是否有货 数量
1 mg ¥5500
In-stock
5 mg ¥9800
In-stock
10 mg ¥15000
In-stock
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100 mg   询价  

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查看 PI4K 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo[1][2]. KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety[2].

IC50 & Target

PI4K

 

体内研究
(In Vivo)

KDU731 (orally administration; 7 or 10mg/kg; 16 days) has potent activity against Cryptosporidium in immunocompromised IFN-γ KO mice and dramatically reduces oocyst shedding[2].
KDU731 (orally administration; 5 mg/kg; every 12 hours for 7 days) is tolerated in all calves, and treated calves shed significantly fewer oocysts than vehicle treated calves in their stool[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 week old C57BL/6 IFN-γ-knockout mice with 10,000 oocysts[1]
Dosage: 7 or 10 mg/kg
Administration: Orally administration; 7 or 10 mg/kg; 16 days
Result: Resulted in significant reduction of oocyst shedding.
Animal Model: Neonatal calves with 5 x 107 oocysts[1]
Dosage: 5 mg/kg
Administration: Orally administration; 5 mg/kg; every 12 hours for 7 days
Result: Resulted in significant reduction of oocyst shedding in treated calves in their stool.
分子量

396.40

Formula

C22H16N6O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 83.33 mg/mL (210.22 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5227 mL 12.6135 mL 25.2270 mL
5 mM 0.5045 mL 2.5227 mL 5.0454 mL
10 mM 0.2523 mL 1.2614 mL 2.5227 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
KDU731
目录号:
HY-103583
需求量: