1. Screening Libraries
  2. PI3K/Akt/mTOR Compound Library

PI3K/Akt/mTOR 化合物库 - PI3K/Akt/mTOR Compound Library

Cat. No.: HY-L015
Library Contents: XLSX PDF SDF

PI3K/Akt/mTOR 信号通路控制着很多和肿瘤发生发展相关的细胞进程,包括细胞凋亡、转录、翻译、代谢、血管生成和细胞周期进程等。这一信号通路的主要节点都在多数人类肿瘤中被激活。该信号通路激活的机制包括 PI3K 上游的酪氨酸激酶受体被激活,编码 PI3K 催化亚基 p110α 的基因 PIK3CA 突变或扩增,抑癌基因 PTEN 的突变或缺失,Akt1 的突变或扩增等。一旦这条信号通路被激活,信号通过 Akt 激活下游一系列底物,包括参与蛋白合成的 mTOR 靶点。因此,抑制该信号通路是癌症预防和/或治疗的有效途径。最近,一些 mTOR 抑制剂已经被批准用对多种癌症的治疗,还有多种新型的 PI3K/Akt/mTOR 抑制剂处于临床研究中。

MCE 收录了 302 个靶向 PI3K/Akt/mTOR 信号通路的小分子化合物,是抗肿瘤药物开发的有用工具。

我们为 MCE PI3K/Akt/mTOR 化合物库 中的所有产品提供溶液包装或粉末包装。溶液包装中,295 个产品以 10 mM 浓度提供,6 个产品以 2 mM 浓度提供,1 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
30 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

Get quote In-stock
50 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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100 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

Get quote In-stock
2 × 100 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

Get quote In-stock

Please contact us at

sales@MedChemExpress.cn

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  • Description

  • Product Details

  • Composition

  • Documentation

Description
& Advantages

•   A unique collection of 302 small molecule inhibitors used for PI3K/Akt/mTOR pathway research.

•   Targets such as Akt, AMPK, DNA-PK, PDK-1, mTOR, PI3K, PTEN, etc.

•   A valuable tool for studying PI3K/Akt/mTOR-related survival, proliferation, and apoptosis of cells and related diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by the FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Rich documentation with structure, IC50, and summary.

•   NMR and HPLC validated to ensure high purity.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 302 PI3K/Akt/mTOR pathway related compounds supplied as pre-dissolved Solutions or Solid
Solution: 295 compounds supplied in 10 mM solution, 6 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
Composition

PI3K/Akt/mTOR Compound Library

Source: MedChem Express

Contents of PI3K/Akt/mTOR Compound Library
Documentation

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    目录号:
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    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack