2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. KIN59

KIN59  (Synonyms: 5'-O-Tritylinosine; 5'-O-Trityl-inosine)

目录号: HY-102071
产品使用指南

摩尔计算器

KIN59 (5'-O-Tritylinosine) 是一种有效的胸苷磷酸化酶 (thymidine phosphorylase) 变构抑制剂。KIN59 抑制 FGF2 刺激的细胞生长。KIN59 抑制 FGF2 (10 ng/mL) 刺激的细胞中 p-FGFR1、P-Akt 的表达。KIN59 具有抗肿瘤活性。

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KIN59 Chemical Structure

KIN59 Chemical Structure

CAS No. : 4152-77-6

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规格 价格 是否有货 数量
5 mg ￥431
3 - 4 周
10 mg ￥691
3 - 4 周
50 mg   询价  
100 mg   询价  

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Customer Review

KIN59 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KIN59 (5’-O-Tritylinosine) is a potent thymidine phosphorylase allosteric inhibitor. KIN59 inhibits FGF2-stimulated cell growth. KIN59 inhibits the expression of p-FGFR1, P-Akt in FGF2 (10 ng/mL) stimulated cells. KIN59 shows anti-tumor activity[1].

体外研究
(In Vitro)

KIN59 (0-100 µM; 24 h) 抑制细胞增殖，对 FGF2 (30 ng/mL) 和 PBS (10%) 刺激的 GM7373 细胞的 IC50 值分别为 5.8 和 63 µM[1].
KIN59 (60 µM; 30 min) 抑制 FGF2 （10 ng/mL）刺激的 FGFR1 过表达 GM7373-FGFR1 细胞中 p-FGFR1、P-Akt 的表达[1]。 KIN59 抑制重组细菌 (大肠杆菌) 和人胸苷磷酸化酶 (TPase)，IC50 值分别为 44 μM 和 67 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KIN59 相关抗体:

Cell Proliferation Assay[1]

Cell Line: GM7373 cells
Concentration: 0-100 µM
Incubation Time: 24 h
Result: Inhibited FGF2 (30 ng/mL)-induced proliferation of bovine macrovascular endothelial GM7373 cells in a dose-dependent manner with IC50 values of 5.8, 63 µM for FGF2 and PBS, respectively.

Western Blot Analysis[1]

Cell Line: GM7373-FGFR1, GM7373-VEGFR2 cells
Concentration: 60 µM
Incubation Time: 30 min
Result: Inhibited FGFR1 phosphorylation and Akt activation triggered by FGF2 in FGFR1-overexpressing GM7373-FGFR1 cells, showed minor inhibits on VEGF-mediated VEGFR2 phosphorylation and Akt activation in GM7373 cells overexpressing VEGFR2.
体内研究
(In Vivo)

KIN59 (15 mg/kg；皮下注射；从第 2 天开始每天两次，持续 20 天) 在小鼠体内显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old female, 25 g, athymic, nude nu/nu mice (F2T-luc2.9 cellss)[1]
Dosage: 15 mg/kg
Administration: S.c.; twice daily from day 2 (once daily during the weekend) at a site distant from the tumor (inoculation) site for 20 days
Result: Caused a significant inhibition in the rate of tumor growth.
分子量

510.54

Formula

C29H26N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KIN59 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KIN594152-77-65'-O-Tritylinosine 5'-O-Trityl-inosineKIN 59KIN-59Nucleoside Antimetabolite/AnalogGM7373 cellsp-FGFR1,P-Aktanti-tumorFGF2Inhibitorinhibitorinhibit

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目录号：
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