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L-Azidonorleucine hydrochloride 

目录号: HY-131033
产品使用指南

L-Azidonorleucine hydrochloride 是一种非天然氨基酸,是 Methionine 的替代物。L-Azidonorleucine hydrochloride 可用于标记哺乳动物细胞蛋白,并鉴定多种甲硫酰基-tRNA 合成酶 (MetRS) 突变体。

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L-Azidonorleucine hydrochloride Chemical Structure

L-Azidonorleucine hydrochloride Chemical Structure

CAS No. : 1454334-76-9

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Description

L-Azidonorleucine hydrochloride, an unnatural amino acid, is A Methionine surrogate. L-Azidonorleucine hydrochloride can be used to label mammalian cell proteins and identify a diverse set of methionyl-tRNA synthetase (MetRS) mutants [1][2].

In Vitro

CHO cells transfected with pMaRSC and incubated with L-Azidonorleucine (Anl; 1.5 mM; 6 h) are fixed, permeabilized, and treated with alkyne-TAMRA. The TAMRA fluorescence exclusively in the mCherry-expressing cells is observed, consistent with cell-selective incorporation of Anl into cellular proteins[1].

In Vivo

When L-Azidonorleucine (ANL) is administered via the drinking water, an average daily L-Azidonorleucine intake of 0.9 mg/day/g of body weight for 21 d when aiming to label and identify neuronal populations of the brain are recommended. Lower dosages or shorter labeling times might be used for the labeling of other cell types. When L-Azidonorleucine is administered by i.p. injection, the testing different L-Azidonorleucine doses in the range of 4-400 mM are recommended. A 400 mM dosage administered by i.p. (i.p. volume: 10 ml/kg) once per day for 1 week is recommended for labeling some neuronal populations (such as excitatory neurons of the hippocampus). Lower dosages (e.g., 4 mM) can potentially be used for labeling other cell types or when longer labeling periods are desired[2].

Molecular Weight

208.65

Formula

C₆H₁₃ClN₄O₂

CAS No.

1454334-76-9

SMILES

N[C@@H](CCCCN=[N+]=[N-])C(O)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

L-AzidonorleucineOthersUnnaturalaminoacidBONCATTAMRAmethionyl-tRNAsynthetaseInhibitorinhibitorinhibit

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产品名称:
L-Azidonorleucine hydrochloride
目录号:
HY-131033
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