1. Anti-infection Cell Cycle/DNA Damage
  2. HBV DNA/RNA Synthesis
  3. LB80317

LB80317 是一种 LB80380 的活性代谢产物,并以 EC50 值为 0.5 μM 来抑制 HBV 的 DNA 合成 (DNA synthesis)。LB80317 具有抗病毒作用,可用于慢性乙型肝炎的研究。

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LB80317 Chemical Structure

LB80317 Chemical Structure

CAS No. : 441785-24-6

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LB80317 is an active metabolite of LB80380 and suppresses the DNA synthesis of HBV with an EC50 of 0.5 μM. LB80317 has antiviral effect and has the potential for chronic hepatitis B treatment[1][2].

IC50 & Target

EC50: 0.5 μM (DNA synthesis of HBV)[2]

体外研究
(In Vitro)

After phosphorylation to di- and triphosphate forms, LB80317 is incorporated into the viral DNA inside the nucleocapsid, which inhibits further DNA synthesis. In in vitro studies using cell line models, the drug concentrations causing 50% reduction in HBV DNA produced (EC50) is 0.5 μM for LB80317[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Forty percent of the amount of LB80331/LB80317 in the mouse liver is detected as the phosphorylated form. LB80380 is rapidly absorbed and converted to LB80331. LB80317 has a long half-life at steady-state (T1/2=8.3-9.9 hours)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

315.22

Formula

C10H14N5O5P

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
LB80317
目录号:
HY-106235
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