2. Apoptosis
  3. Ferroptosis
  4. Lepadin H

Lepadin H 是一种海洋生物碱和铁死亡诱导剂。 Lepadin H 表现出显著的细胞毒性，促进 p53 表达，增加 ROS 产生和脂质过氧化，降低 SLC7A11 和 GPX4 水平，并上调 ACSL4 表达。 Lepadin H 通过 p53-SLC7A11-GPX4 途径诱导铁死亡。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Lepadin H

Lepadin H Chemical Structure

CAS No. : 412328-25-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Lepadin H 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
4.68 μM
Compound: Lepadin H
Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay
[PMID: 37578947]
B16-F10 IC50
3.14 μM
Compound: Lepadin H
Cytotoxicity against mouse B16-F10 cells incubated for 72 hrs by MTT assay
Cytotoxicity against mouse B16-F10 cells incubated for 72 hrs by MTT assay
[PMID: 37578947]
HeLa IC50
2.52 μM
Compound: Lepadin H
Cytotoxicity against human HeLa cells incubated for 72 hrs by MTT assay
Cytotoxicity against human HeLa cells incubated for 72 hrs by MTT assay
[PMID: 37578947]
HepG2 IC50
6.2 μM
Compound: Lepadin H
Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay
[PMID: 37578947]
L02 IC50
12.49 μM
Compound: Lepadin H
Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay
[PMID: 37578947]
MCF7 IC50
5.03 μM
Compound: Lepadin H
Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 37578947]
MDA-MB-231 IC50
8.51 μM
Compound: Lepadin H
Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
[PMID: 37578947]
NCI-H1155 IC50
7.06 μM
Compound: Lepadin H
Cytotoxicity against human NCI-H1155 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H1155 cells incubated for 72 hrs by MTT assay
[PMID: 37578947]
NCI-H1355 IC50
9.3 μM
Compound: Lepadin H
Cytotoxicity against human NCI-H1355 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H1355 cells incubated for 72 hrs by MTT assay
[PMID: 37578947]
SH-SY5Y IC50
5.8 μM
Compound: Lepadin H
Cytotoxicity against human SH-SY5Y cells incubated for 72 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells incubated for 72 hrs by MTT assay
[PMID: 37578947]
SK-OV-3 IC50
8.02 μM
Compound: Lepadin H
Cytotoxicity against human SK-OV-3 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human SK-OV-3 cells incubated for 72 hrs by MTT assay
[PMID: 37578947]
SMMC-7721 IC50
4.09 μM
Compound: Lepadin H
Cytotoxicity against human SMMC-7721 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human SMMC-7721 cells incubated for 72 hrs by MTT assay
[PMID: 37578947]
分子量

419.64

Formula

C26H45NO3
CAS 号
结构分类
初始来源

Tropical Marine Tunicate Didemnum sp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lepadin H 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lepadin H412328-25-7Ferroptosisferroptosis inducerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Lepadin H
目录号：
HY-155852
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z