2. Anti-infection
  3. CMV
  4. Letermovir

Letermovir  (Synonyms: AIC246; MK-8228)

目录号: HY-15233G
产品使用指南 技术支持

Letermovir (GMP) 是 Letermovir (HY-15233) 的 GMP 级别。Letermovir (GMP) 是一种口服有效的 CMV 的抑制剂。Letermovir (GMP) 针对 CMV 末端酶复合物而不是 CMV DNA 聚合酶，发挥抗病毒作用。Letermovir (GMP) 可用于 CMV 感染的研究。

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Letermovir

Letermovir Chemical Structure

CAS No. : 917389-32-3

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100 mg   询价  
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Letermovir 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Letermovir (GMP) is the GMP grade of Letermovir (HY-15233). Letermovir (GMP) is an orally active CMV inhibitor. Letermovir (GMP) targets the CMV terminase complex rather than CMV DNA polymerase and exerts its antiviral activity. Letermovir (GMP) can be used in the study of CMV infection[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEL EC50
0.0046 μM
Compound: Letermovir
Antiviral activity against Cytomegalovirus AD-169 infected in HEL cells assessed as reduction of virus-induced cytopathogenicity
Antiviral activity against Cytomegalovirus AD-169 infected in HEL cells assessed as reduction of virus-induced cytopathogenicity
[PMID: 26001344]
HEL 299 CC50
63 μM
Compound: AIC246
Cytotoxicity against HEL299 cells infected with human cytomegalovirus after 7 days by alamar blue assay
Cytotoxicity against HEL299 cells infected with human cytomegalovirus after 7 days by alamar blue assay
[PMID: 20047911]
HEL 299 EC50
0.0035 μM
Compound: AIC246
Antiviral activity against human cytomegalovirus infected in HEL299 cells after 7 days by GFP-based fluorescent reduction assay
Antiviral activity against human cytomegalovirus infected in HEL299 cells after 7 days by GFP-based fluorescent reduction assay
[PMID: 20047911]
HS27 CC50
107 μM
Compound: AIC246
Cytotoxicity against human HS27 cells infected with human cytomegalovirus after 7 days by alamar blue assay
Cytotoxicity against human HS27 cells infected with human cytomegalovirus after 7 days by alamar blue assay
[PMID: 20047911]
HS27 EC50
0.0056 μM
Compound: AIC246
Antiviral activity against human cytomegalovirus infected in human HS27 cells after 7 days by GFP-based fluorescent reduction assay
Antiviral activity against human cytomegalovirus infected in human HS27 cells after 7 days by GFP-based fluorescent reduction assay
[PMID: 20047911]
MRC5 CC50
127 μM
Compound: AIC246
Cytotoxicity against human MRC5 cells infected with human cytomegalovirus after 7 days by alamar blue assay
Cytotoxicity against human MRC5 cells infected with human cytomegalovirus after 7 days by alamar blue assay
[PMID: 20047911]
MRC5 EC50
0.0045 μM
Compound: AIC246
Antiviral activity against human cytomegalovirus infected in human MRC5 cells after 7 days by GFP-based fluorescent reduction assay
Antiviral activity against human cytomegalovirus infected in human MRC5 cells after 7 days by GFP-based fluorescent reduction assay
[PMID: 20047911]
NHDF CC50
91 μM
Compound: AIC246
Cytotoxicity against NHDF infected with human cytomegalovirus after 7 days by alamar blue assay
Cytotoxicity against NHDF infected with human cytomegalovirus after 7 days by alamar blue assay
[PMID: 20047911]
Clinical Trial
分子量

572.55

Formula

C29H28F4N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Letermovir 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Letermovir (GMP)917389-32-3AIC246 (GMP)MK-8228 (GMP)CMVCytomegalovirusGMPvirusinfectionInhibitorinhibitorinhibit

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目录号：
HY-15233G
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