2. GPCR/G Protein
  3. Oxytocin Receptor
  4. LIT-001 free base

LIT-001 free base 是第一种非肽类催产素受体 (OT-R) 激动剂 (EC50=55 nM; Ki=226 nM)。LIT-001 free base 改善孤独症小鼠模型的社交互动。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 LIT-001 通常具有更好的水溶性和稳定性。

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LIT-001 free base Chemical Structure

LIT-001 free base Chemical Structure

CAS No. : 2245072-20-0

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LIT-001 free base 的其他形式现货产品:

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LIT-001 free base 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001 free base improves social interaction in a mouse model of autism[1].

体外研究
(In Vitro)

In vitro signaling experiments, LIT-001 free base is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LIT-001 free base 相关抗体:
体内研究
(In Vivo)

LIT-001 free base (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Oprm1–/– mice (bred in house on a 50% 129SVPas–50% C57BL/6J hybrid background)[1]
Dosage: 10, 20 mg/kg
Administration: i.p.
Result: Alleviated core symptoms in the context of ASD.
分子量

531.67

Formula

C28H33N7O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LIT-001 free base 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LIT-0012245072-20-0LIT001LIT 001Oxytocin ReceptorOXTRnonpeptidesocialinteractionV1aV2vasopressinreceptorautismspectrumdisordersnonbiasedInhibitorinhibitorinhibit

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