1. Apoptosis Immunology/Inflammation
  2. TNF Receptor Interleukin Related
  3. LMP-420

LMP-420 是一种选择性的肿瘤坏死因子-α (TNF-α) 抑制剂。LMP-420 能够减少促炎细胞因子 (如 IL-1β、IL-2) 的释放,诱导抗炎细胞因子 IL-10 以及抗凋亡分子 SOCS-1 和 Mn-SOD 的表达。LMP-420 还能下调趋化因子 (如 IP-10、MCP-1) 的水平,从而减少免疫细胞的浸润。LMP-420 有望用于 1 型糖尿病、炎症性疾病 (如结肠炎) 以及 HIV-结核分枝杆菌共感染的研究。

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LMP-420

LMP-420 Chemical Structure

CAS No. : 473870-63-2

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  • 生物活性

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生物活性

LMP-420 is a selective tumor necrosis factor-α (TNF-α) inhibitor. LMP-420 reduces the release of pro-inflammatory cytokines (e.g., IL-1β, IL-2), inducing the expression of anti-inflammatory cytokine IL-10 and anti-apoptotic molecules SOCS-1 and Mn-SOD. LMP-420 also downregulates chemokines (e.g., IP-10, MCP-1) to reduce immune cell infiltration. LMP-420 is promising for research of type 1 diabetes mellitus, inflammatory diseases (e.g., colitis), and HIV-Mycobacterium tuberculosis coinfection[1].

分子量

283.52

Formula

C10H15BClN5O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
LMP-420
目录号:
HY-124665
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