1. Epigenetics
  2. Histone Acetyltransferase
  3. Lys-CoA TFA

Lys-CoA TFA 

目录号: HY-131035
产品使用指南

Lys-CoA TFA 是一种选择性 p300 组蛋白乙酰转移酶 (HAT) 抑制剂 (IC50=50-500 nM)。Lys-CoA TFA 对 p300 的选择性是 PCAF 的 100 多倍 (IC50=200 μM)。Lys-CoA TFA 抑制 p300-HAT 活性依赖的转录激活。

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Lys-CoA TFA Chemical Structure

Lys-CoA TFA Chemical Structure

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Description

Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC50=50-500 nM). Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC50=200 μM). Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation[1][2].

IC50 & Target[1]

p300

50-500 nM (IC50)

In Vitro

Lys-CoA TFA (0.1 and 1 mM; 60 hours) induces a senescent phenotype in human normal melanocytes[3].

Cell Proliferation Assay[3]

Cell Line: Normal human melanocytes
Concentration: 0.1 and 1 mM
Incubation Time: 60 hours
Result: Almost completely abolished proliferation, induced high levels of SA-β-Gal, and inhibited cyclin E expression in a dose-dependent manner.
Molecular Weight

1108.82

Formula

C₃₃H₅₄F₃N₁₀O₂₁P₃S

SMILES

OC(C(F)(F)F)=O.O[C@H](C(C)(COP(OP(OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C2N=CN=C3N)O)OP(O)(O)=O)(O)=O)(O)=O)C)C(NCCC(NCCSCC(NCCCC[C@H](NC(C)=O)C(N)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Lys-CoAHistone AcetyltransferaseHATsHATselectivityp300histoneacetyltransferasetranscriptionalsenescentphenotypeInhibitorinhibitorinhibit

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产品名称:
Lys-CoA TFA
目录号:
HY-131035
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