2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. MC2625

MC2625 是一种有效的含吡啶的组蛋白脱乙酰酶 (HDAC) 抑制剂。MC2625 显示选择性 HDAC3 和 HDAC6 抑制作用，IC50 分别为 80 nM 和 11 nM。MC2625 增加乙酰-H3 和乙酰-微管蛋白水平，并通过细胞凋亡诱导抑制癌症干细胞 (CSC) 的生长。

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MC2625 Chemical Structure

MC2625 Chemical Structure

CAS No. : 1776116-75-6

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MC2625 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MC2625 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2625 show selective HDAC3 and HDAC6 inhibition with IC50s of 80 nM and 11 nM. MC2625 increases acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells (CSCs) growth by apoptosis induction[1][2].

IC50 & Target[1][2]

HDAC3

80 nM (IC50)

HDAC6

11 nM (IC50)

HDAC1

1.42 μM (IC50)

HDAC2

1.77 μM (IC50)

HDAC4

11.7 μM (IC50)

HDAC5

9.37 μM (IC50)

HDAC7

8.77 μM (IC50)

HDAC8

0.61 μM (IC50)

HDAC9

10.6 μM (IC50)

HDAC10

1.8 μM (IC50)

HDAC11

10.2 μM (IC50)

体外研究
(In Vitro)

MC2625 (0.5-2 μM; 24-72 小时) 在 72 h 后对不同的肉瘤癌症干细胞 (CSCs) 具有有效的抗增殖作用[1]。
MC2625 (0.5-2 μM; 48 小时) 显着诱导所有 CSC 培养物的细胞凋亡，A204 CSCs 除外[1]。
MC2625 (0.5, 2 μM; 24 小时) 引起乙酰组蛋白 H3 的剂量依赖性增加[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MC2625 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Cancer stem cells (HOS, MG-63, RD, A204, SK-ES-1, A673)
Concentration: 0.5, 1, 2 μM
Incubation Time: 24, 48, 72 h
Result: Significantly affected MG-63, RD, and SK-ES-1 viability in 0.5 μM, while all CSCs were sensitive at 1 and 2 μM.

Apoptosis Analysis[1]

Cell Line: Cancer stem cells (HOS, MG-63, RD, A204, SK-ES-1, A673)
Concentration: 0.5, 1, 2 μM
Incubation Time: 48 h
Result: Significantly induced apoptosis of all CSC cultures, with the exception of A204 CSCs.
Generated an increase of the presence of apoptotic cells with concentrated dense granular fluorescence compared to untreated cells, especially at 1 and 2 μM.

Western Blot Analysis[1]

Cell Line: MG-63 cancer stem cells
Concentration: 0.5, 2 μM
Incubation Time: 24 h
Result: Caused a dose-dependent increase of acetyl-histone H3.
分子量

387.43

Formula

C23H21N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MC2625 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC26251776116-75-6MC 2625MC-2625HDACApoptosisHistone deacetylasesPyridinehistone deacetylaseHDAC3HDAC6HDAC1HDAC2HDAC4HDAC5HDAC7HDAC8HDAC9HDAC10HDAC11acetyl-H3acetyl-tubulinCSCs,Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-152225
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