2. Academic Validation
  3. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

  • Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7. doi: 10.1016/j.bmcl.2012.02.105.
Aesop Cho 1,  Oliver L Saunders,  Thomas Butler,  Lijun Zhang,  Jie Xu,  Jennifer E Vela,  Joy Y Feng,  Adrian S Ray,  Choung U Kim
Affiliations

Affiliation

  • 1 Gilead Sciences, 333 Lakeside Drive, Foster Cit, CA 94044, USA. acho@gilead.com
PMID: 22446091 DOI: 10.1016/j.bmcl.2012.02.105
Abstract

A series of 1'-substituted analogs of 4-aza-7,9-dideazaadenosine C-nucleoside were prepared and evaluated for the potential as Antiviral agents. These compounds showed a broad range of inhibitory activity against various RNA viruses. In particular, the whole cell potency against HCV when R=CN was attributed to inhibition of HCV NS5B polymerase and intracellular concentration of the corresponding nucleoside triphosphate.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z