1. MAPK/ERK Pathway PI3K/Akt/mTOR Cell Cycle/DNA Damage
  2. MEK PI3K PERK
  3. MEK/PI3K-IN-1

MEK/PI3K-IN-1 (compound 6r) 是一种有效的 MEK/PI3K 抑制剂,其IC50 值分别为 124 nM (MEK1), 130 nM (PI3Kα), 和 236 nM (PI3Kδ)。MEK/PI3K-IN-1 抑制 pAKT 和 pERK1/2 水平。MEK/PI3K-IN-1 对肿瘤细胞具有抗增殖活性。

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MEK/PI3K-IN-1 Chemical Structure

MEK/PI3K-IN-1 Chemical Structure

CAS No. : 2281803-28-7

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MEK/PI3K-IN-1 (compound 6r) is a potent MEK/PI3K inhibitor, with IC50 values of 124 nM (MEK1), 130 nM (PI3Kα), and 236 nM (PI3Kδ), respectively. MEK/PI3K-IN-1 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-1 shows anti-proliferative activity against tumor cell lines[1].

IC50 & Target

MEK1

124 ± 11 nM (IC50)

PI3Kα

130 ± 13 nM (IC50)

PI3Kδ

236 ± 29 nM (IC50)

PI3Kβ

1537 ± 188 nM (IC50)

PI3Kγ

2745 ± 485 nM (IC50)

分子量

913.63

Formula

C36H37F5IN9O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
MEK/PI3K-IN-1
目录号:
HY-144692
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