1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Mepivacaine

Mepivacaine 

目录号: HY-B0517 纯度: >98.0%
产品使用指南

Mepivacaine 是一种酰胺型药剂,可暂时使局部失去知觉。Mepivacaine 与神经元细胞膜上特定的电压门控钠离子通道结合,抑制钠离子内流和膜去极化。

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Mepivacaine Chemical Structure

Mepivacaine Chemical Structure

CAS No. : 96-88-8

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500 mg ¥650 In-stock
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Description

Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization[1][2].

In Vitro

Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action[2].
Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine)[3].
Mepivacaine displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels[4].

Molecular Weight

246.35

Formula

C₁₅H₂₂N₂O

CAS No.

96-88-8

SMILES

O=C(C(CCCC1)N1C)NC(C(C)=CC=C2)=C2C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (135.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0593 mL 20.2963 mL 40.5927 mL
5 mM 0.8119 mL 4.0593 mL 8.1185 mL
10 mM 0.4059 mL 2.0296 mL 4.0593 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MepivacaineSodium ChannelNa channelsNa+ channelsamide-typelocalanestheticneuronalcelldepolarizationInhibitorinhibitorinhibit

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HY-B0517
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